Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
8-Quinolinol,5-(chloromethyl)- |
EINECS | N/A |
CAS No. | 10136-57-9 | Density | 1.355 g/cm3 |
PSA | 33.12000 | LogP | 3.48120 |
Solubility | N/A | Melting Point |
180 °C |
Formula | C10H8ClNO | Boiling Point | 388.1 ºC at 760 mmHg |
Molecular Weight | 193.633 | Flash Point | 188.5 ºC |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
5-Chloromethyl-8-hydroxyquinoline;5-Chloromethyl-8-quinolinol;5-(chloromethyl)quinolin-8-ol; |
Article Data | 27 |
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; for 12h; | 91.4% |
With hydrogenchloride In water at 0 - 60℃; for 10h; | 90% |
With hydrogenchloride In water at 80℃; for 6h; | 87% |
5-(hydroxymethyl)-8-hydroxyquinoline
5-(chloromethyl)quinolin-8-ol
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; for 6h; |
5-(chloromethyl)quinolin-8-ol
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 88% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 48h; | 81% |
5-(chloromethyl)quinolin-8-ol
(1-1-benzylpiperidin-4-yl)(prop-2-yn-1-yl-amino)acetonitrile
2-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)acetonitrile
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 80.6% |
With triethylamine In dichloromethane at 20℃; for 0.5h; | 80.6% |
5-(chloromethyl)quinolin-8-ol
5-(aminomethyl)-8-hydroxyquinoline
5,5',5''-nitrilotris(methylene)triquinolin-8-ol
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 50℃; for 24h; | 73% |
5-(chloromethyl)quinolin-8-ol
5-(aminomethyl)-8-hydroxyquinoline
Conditions | Yield |
---|---|
Stage #1: 5-(chloromethyl)quinolin-8-ol With hexamethylenetetramine In dimethyl sulfoxide at 20℃; Stage #2: With hydrogenchloride In water at 20℃; for 48h; | 70% |
Stage #1: 5-(chloromethyl)quinolin-8-ol With potassium phtalimide In N,N-dimethyl-formamide at 150℃; for 5h; Stage #2: With hydrogenchloride In water at 150℃; for 9h; | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 5 h / 150 °C 2: hydrogenchloride / water / 20 °C / Reflux View Scheme |
5-(chloromethyl)quinolin-8-ol
3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile
3-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)propanenitrile
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 69.5% |
5-(chloromethyl)quinolin-8-ol
4-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)butanenitrile
4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 65.4% |
With triethylamine In dichloromethane at 0 - 20℃; | 65.4% |
piperazine
5-(chloromethyl)quinolin-8-ol
5,5'-(piperazine-1,4-diylbis(methylene))diquinolin-8-ol
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; for 72h; | 60% |
Systematic Name: 5-(Chloromethyl)quinolin-8-ol
SMILES: ClCc1ccc(O)c2ncccc12
InChI: InChI=1/C10H8ClNO/c11-6-7-3-4-9(13)10-8(7)2-1-5-12-10/h1-5,13H,6H2
InChIKey: JGOBHUWKRDXZEY-UHFFFAOYAW
Empirical Formula: C10H8ClNO
Molecular Weight: 193.6296
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 2
Index of Refraction: 1.677
Molar Refractivity: 53.83 cm3
Molar Volume: 142.8 cm3
Surface Tension: 58.6 dyne/cm
Density: 1.355 g/cm3
Flash Point: 188.5 °C
Enthalpy of Vaporization: 66.22 kJ/mol
Boiling Point: 388.1 °C at 760 mmHg
Vapour Pressure: 1.41E-06 mmHg at 25 °C
8-Quinolinol,5-(chloromethyl)- (CAS NO.10136-57-9), its Synonyms are 5-(chloromethyl)quinolin-8-ol ; 5-Chloromethyl-8-quinolinol ; 5-Chloromethyl-8-hydroxyquinoline .