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1-Piperidineethanol,4-amino-
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Name

1-Piperidineethanol,4-amino-

 EINECS N/A
CAS No. 89850-72-6 Density 1.028 g/cm3
PSA 49.49000 LogP 0.04000
Solubility at 25 deg C (mg/L): 1e+006 Melting Point N/A
Formula C7H16N2O Boiling Point 250.4 °C at 760 mmHg
Molecular Weight 144.217 Flash Point 105.3 °C
Transport Information N/A Appearance N/A
Safety 26-39 Risk Codes 22-37/38-41
Molecular Structure Molecular Structure of 89850-72-6 (4-AMINO-1-PIPERIDINE-ETHANOL) Hazard Symbols Xn
Synonyms

2-(4-Aminopiperidin-1-yl)ethanol;4-Amino-1-piperidineethanol;

Article Data 5

1-Piperidineethanol,4-amino- Synthetic route

558443-53-1

[1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
With trifluoroacetic acid at 20℃; for 1h;95%
With hydrogenchloride In ethanol; water for 2h; Reflux;95%
With hydrogenchloride In ethanol for 2h; Reflux;95%
Stage #1: [1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester With trifluoroacetic acid
Stage #2: With hydrogenchloride In methanol at 20℃; for 0.5h;
Stage #3: With sodium hydroxide In water at 20℃; for 0.25h; pH=> 10; Cooling with ice;		87%
51527-83-4

Br(1-)*C7H11N2O(1+)

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
Stage #1: Br(1-)*C7H11N2O(1+) With hydrogen; sodium; rhodium contaminated with carbon In methanol at 60℃; under 7240.26 Torr;
Stage #2: In methanol Reflux;		69%
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / K2CO3 / acetonitrile / 5 h / Heating
2: 95 percent / TFA / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 5 h / Reflux
2.1: trifluoroacetic acid
2.2: 0.5 h / 20 °C
2.3: 0.25 h / 20 °C / pH > 10 / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 5 h / Reflux
2: hydrogenchloride / ethanol; water / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 5 h / Reflux
2: hydrogenchloride / ethanol / 2 h / Reflux
View Scheme
504-24-5

4-aminopyridine

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene / 3.5 h / Reflux
2.1: hydrogen; sodium / rhodium contaminated with carbon / methanol / 60 °C / 7240.26 Torr
2.2: Amberlyst 15 resin / Reflux
View Scheme
1421000-02-3

2,6-dichloro-N-(2-ethylhexyl)nicotinamide

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

1420999-78-5

6-chloro-N-(2-ethylhexyl)-2-{[1-(2-hydroxyethyl)piperidin-4-yl]amino}nicotinamide

Conditions
ConditionsYield
With potassium carbonate In o-xylene for 24h; Reflux;77.9%
With potassium carbonate In o-xylene for 24h; Reflux;77.9%
619-58-9

4-iodobenzoic acid

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

C14H19IN2O2

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 20h;50%
586-76-5

4-Bromobenzoic acid

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

4-bromo-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 20h;40%

(R)-1-(3-((3'-(3-bromopropoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

(R)-1-(3-((3'-(3-((1-(2-hydroxyethyl)piperidin-4-yl)amino)propoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In methanol at 65℃; for 72h; Inert atmosphere;34%
89891-65-6

7-bromo-2-chloroquinoxaline

89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

1345444-82-7

C15H19BrN4O

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 24h;32%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 24h;32%
89850-72-6

4-amino-1-(2-hydroxyethyl)piperidine

1H-1,2,3-benzotriazol-1-yl 4-amino-3-methoxybenzoate

1201694-09-8

4-amino-N-[1-(2-hydroxy-ethyl)-piperidin-4-yl]-3-methoxy-benzamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide

1-Piperidineethanol,4-amino- Specification

The 1-Piperidineethanol, 4-amino-, with the CAS registry number of 89850-72-6, is also known as 2-(4-Amino-1-piperidinyl)ethanol. This chemical's molecular formula is C7H16N2O and molecular weight is 144.21. What's more, its IUPAC name is 2-(4-Aminopiperidin-1-yl)ethanol.

Physical properties about 1-Piperidineethanol, 4-amino- are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 3; (6)#H bond donors: 3; (7)#Freely Rotating Bonds: 4; (8)Polar Surface Area: 49.49 Å2; (9)Index of Refraction: 1.497; (10)Molar Refractivity: 41.03 cm3; (11)Molar Volume: 140.1 cm3; (12)Surface Tension: 39.6 dyne/cm; (13)Density: 1.028 g/cm3; (14)Flash Point: 105.3 °C; (15)Enthalpy of Vaporization: 56.66 kJ/mol; (16)Boiling Point: 250.4 °C at 760 mmHg; (17)Vapour Pressure: 0.00344 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: OCCN1CCC(N)CC1
(2) InChI: InChI=1/C7H16N2O/c8-7-1-3-9(4-2-7)5-6-10/h7,10H,1-6,8H2
(3) InChIKey: NMWIFNPFFNFXPB-UHFFFAOYAK

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