92552-22-2

Basic information

• Product Name: 2-BENZYLOXYPHENYLACETONITRILE
• Synonyms: 2-Benzyloxybenzyl cyanide;2-Benzyloxyacetonitrile
• CAS NO: 92552-22-2
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.27
• Product Categories: Aromatic Nitriles
• Mol File: 92552-22-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 112 °C
• Flash Point: 102.4°C
• Appearance: /
• Density: 1,54g/cm
• Vapor Pressure: 0.0276mmHg at 25°C
• Refractive Index: 1.519
• BRN: 2731076
• CAS DataBase Reference: 2-BENZYLOXYPHENYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLOXYPHENYLACETONITRILE(92552-22-2)
• EPA Substance Registry System: 2-BENZYLOXYPHENYLACETONITRILE(92552-22-2)

Safety Data

• Hazard Codes: Xi
• Statements: 22-36/37/38
• Safety Statements: 36/37-36-26
• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 92552-22-2(Hazardous Substances Data)

Usage

General Description

2-BENZYLOXYPHENYLACETONITRILE is a chemical compound with the molecular formula C16H13NO. It is a white to off-white solid and is commonly used as an intermediate in the synthesis of various pharmaceutical compounds and organic chemicals. 2-BENZYLOXYPHENYLACETONITRILE is often used in the production of pharmaceuticals such as nonsteroidal anti-inflammatory drugs (NSAIDs), as well as in the synthesis of other organic compounds. 2-BENZYLOXYPHENYLACETONITRILE is also used as a building block in the production of other chemicals, and its versatility and stability make it a valuable compound in the field of organic chemistry.

InChI:InChI=1/C9H9NO/c10-6-7-11-8-9-4-2-1-3-5-9/h1-5H,7-8H2

Upstream product

• 92963-94-5 2-Benzyloxy-phenylbrenztraubensaeure-oxim 
• 143-33-9 sodium cyanide 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 13435-20-6 tetraethylammoniumcyanide 
• 23915-08-4 2-benzyloxybenzyl chloride 
• 90-01-7 salicylic alcohol 
• 3381-87-1 2-benzyloxybenzyl alcohol 
• 100-39-0 benzyl bromide 
• 89-95-2 2-methyl-benzyl alcohol 
• 74511-44-7 o-(benzyloxy)benzonitrile 
• 14389-86-7 2-benzyloxybenzoic acid 
• 773837-37-9 sodium cyanide 
• 611-20-1 salicylonitrile 

Downstream Products

• 40525-65-3 2-benzyloxyphenylacetic acid methyl ester 
• 881672-60-2 2,2-dimethyl-propionic acid 2-(2-benzyloxy-phenyl)-3-hydroxy-propyl ester 
• 881672-71-5 dimethyl 2-[2-(benzyloxy)benzyl]malonate 
• 881672-73-7 2-[2-(benzyloxy)phenyl]-1,3-propanediol 
• 881672-54-4 2,2-dimethyl-propionic acid 3-hydroxy-2-(2-hydroxy-phenyl)-propyl ester 
• 22047-88-7 2-hydroxyphenylacetic acid benzyl ether 
• 860114-04-1 4-(2-benzyloxy-phenyl)-1-methyl-piperidine-4-carbonitrile 
• 65576-45-6 asenapine 
• 22136-46-5 N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid 
• 251359-94-1 4-(4-Chlorophenyl)-4-hydroxy-α-[2-(phenylmethoxy)-phenyl]-1-piperidinepentanenitrile 

Relevant articles and documents

High diastereoselectivity in the yang photocyclization via remote hydrogen abstraction reaction

1-Benzoyl-1-(o-alkoxyphenyl)cyclopropanes undergo Yang photocyclization to form dihydrobenzopyranols in a stereospecific manner. The cyclopropyl group at alpha position to carbonyls gives not only a bias in the most stable geometries of the starting ketones but also conformational restriction on geometries of biradical intermediates. More importantly, intramolecular hydrogen bonds seem to give an additional effect on conformational control of the biradical reactivity.

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.