890130-35-5

Basic information

• Product Name: 3-tert-butyl-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-5-amine
• Synonyms: 3-tert-butyl-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-5-amine
• CAS NO: 890130-35-5
• Molecular Weight: 257.379
• Mol File: 890130-35-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 384.0±37.0 °C(Predicted)
• Density: 1.04±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 3-tert-butyl-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tert-butyl-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-5-amine(890130-35-5)
• EPA Substance Registry System: 3-tert-butyl-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-5-amine(890130-35-5)

Safety Data

• Hazardous Substances Data: 890130-35-5(Hazardous Substances Data)

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 118427-29-5 (4-isopropylphenyl)hydrazine hydrochloride 
• 63693-65-2 4-isopropylphenylhydrazine 

Downstream Products

• 1071964-58-3 1-(3-tert-butyl-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea 

Relevant articles and documents

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-a agents that Target the p38 MAPK Pathway

A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-a production in lipopolysaccharide-stimulated THP-1 cells. The most active compound, 40g, inhibited TNF-a release with an IC50 value of 0.033 μM, which is equipotent to that of BIRB796 (IC50 = 0.032 μM).