887903-03-9

Basic information

• Product Name: 4-fluoro-2-ethynylaniline
• Synonyms: 4-fluoro-2-ethynylaniline
• CAS NO: 887903-03-9
• Molecular Weight: 135.141
• Mol File: 887903-03-9.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 4-fluoro-2-ethynylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-2-ethynylaniline(887903-03-9)
• EPA Substance Registry System: 4-fluoro-2-ethynylaniline(887903-03-9)

Safety Data

• Hazardous Substances Data: 887903-03-9(Hazardous Substances Data)

Upstream product

• 1003-98-1 2-bromo-4-fluoroaniline 
• 371-40-4 4-fluoroaniline 
• 61272-76-2 4-fluoro-2-iodoaniline 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 604797-61-7 5-fluoro-2,3-diphenyl-1H-indole 
• 2343-25-1 5-fluoro-2-amino-acetophenone 
• 399-52-0 5-fluoro-1H-indole 

Relevant articles and documents

COMBINATION PRODUCT FOR THE TREATMENT OF CANCEROUS DISEASES

The present invention relates to a product for combination therapies useful for the treatment of cancer diseases. In particular, the invention relates to the combination of an anti-PD-Ll antibody and an MCT4 inhibitor of Formula (I). The therapeutic combination may be utilized for the use in treating a subject having a cancer disease that tests positive for PD-L1 and/or MCT4 expression.

Sequential Sonogashira/intramolecular aminopalladation/cross-coupling ofortho-ethynyl-anilines catalyzed by a single palladium source: rapid access to 2,3-diarylindoles

We have developed a practical and efficient one-pot protocol for the synthesis of 2,3-diarylindolesviaPd-catalyzed bis-arylative cyclization of variouso-ethynylanilines with aryl iodides. Mechanism studies showed that a Pd-catalyzed Sonogashira reaction took place firstly, giving an internal alkyne intermediate, which subsequently underwent intramolecular aminopalladation/cross-coupling to give access to 2,3-diarylindoles. The present methodology exhibits a broad substrate scope, producing various 2,3-diaryl indoles bearing two different aryl groups.

Photoinduced Radical Cascade Cyclization: A Metal-Free Approach to Access Difluoroalkylated Dioxodibenzothiazepines

A simple and mild photoredox catalytic approach to access difluoroalkylated dioxodibenzothiazepines in high regioselectivity via radical cascade cyclization has been described herein. In contrast to previous methods, this strategy does not involve the use