2343-25-1 Usage
Description
2-AMINO-5-FLUOROACETOPHENONE is an organic compound that serves as a valuable research chemical and intermediate in the synthesis of various organic and pharmaceutical compounds. It is characterized by its unique molecular structure, which features a fluorine atom at the 5-position and an amino group at the 2-position on the acetophenone backbone.
Uses
Used in Research and Development:
2-AMINO-5-FLUOROACETOPHENONE is used as a research chemical for the development of new organic and pharmaceutical compounds. Its unique structure makes it a versatile building block in the synthesis of various molecules with potential applications in different fields.
Used in Organic Synthesis:
2-AMINO-5-FLUOROACETOPHENONE is used as an organic synthesis intermediate, playing a crucial role in the production of a wide range of organic compounds. Its reactivity and functional groups allow for various chemical reactions, leading to the formation of diverse molecules with specific properties and applications.
Used in Pharmaceutical Industry:
2-AMINO-5-FLUOROACETOPHENONE is used as a pharmaceutical intermediate, contributing to the development of new drugs and therapeutic agents. Its unique structure and reactivity make it an essential component in the synthesis of various pharmaceutical compounds, potentially leading to the discovery of novel treatments for various diseases and conditions.
Synthesis
600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 °C for 36 hours.After the reaction, the temperature is lowered to 20-25 °C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 °C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 °C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%.
Check Digit Verification of cas no
The CAS Registry Mumber 2343-25-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,4 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2343-25:
(6*2)+(5*3)+(4*4)+(3*3)+(2*2)+(1*5)=61
61 % 10 = 1
So 2343-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H8FNO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-4H,10H2,1H3
2343-25-1Relevant articles and documents
Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones
Wang, Rong-Hui,Li, Ya-Ling,He, Hong-Jiao,Xiao, You-Cai,Chen, Fen-Er
supporting information, p. 4302 - 4306 (2021/02/16)
The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.
Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks
Li, Liping,Gao, Hui,Sun, Ming,Zhou, Zhi,Yi, Wei
supporting information, p. 5473 - 5478 (2020/07/14)
Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.
Chemoselective Alkylation of Aminoacetophenones with Alcohols by Using a Palladacycle-Phosphine Catalyst
Mamidala, Ramesh,Subramani, M. Siva,Samser, Shaikh,Biswal, Priyabrata,Venkatasubbaiah, Krishnan
supporting information, p. 6286 - 6296 (2018/11/23)
The development of efficient and environmentally benign palladacycle-phosphine catalyzed process to enable the formation of chemoselective C-alkylated or N-alkylated aminoacetophenones with alcohols is described. This methodology proved to be tunable by variation of the base and the temperature, which allows for the isolation of structurally diverse C-alkylated and N-alkylated aminoacetophenones. Moreover, this methodology has been applied to the synthesis of biologically and industrially important donepezil.
