87344-06-7 Usage
Description
Amtolmetin guacil is an orally active non-steroidal anti-inflammatory drug (NSAID) that is primarily used for the treatment of osteoarthritis, rheumatoid arthritis, and post-operative pain. It is a non-acidic prodrug of tolmetin, which means it is converted into the active drug in the body. Amtolmetin guacil has been reported to provide a more rapid and improved analgesic action compared to other agents such as paracetamol. In models of adjuvant arthritis and rheumatic diseases, it has shown to be more efficacious than existing drugs like naproxen, indomethacin, and piroxicam. Additionally, it has minor ulcerogenic action, lower acute toxicity, and excellent biological and gastric tolerability.
Uses
Used in Pharmaceutical Industry:
Amtolmetin guacil is used as an analgesic and anti-inflammatory agent for the treatment of rheumatoid arthritis. It is effective in reducing pain and inflammation associated with the condition, improving the quality of life for patients.
Used in Orthopedic Industry:
Amtolmetin guacil is used for the treatment of osteoarthritis, a degenerative joint disease that affects millions of people worldwide. It helps to alleviate the pain and inflammation associated with this condition, allowing patients to maintain an active lifestyle.
Used in Post-operative Pain Management:
Amtolmetin guacil is used as a post-operative pain management agent, providing effective pain relief following surgical procedures. Its rapid and improved analgesic action makes it a valuable option for patients recovering from surgery.
Used in Drug Development Research:
Amtolmetin guacil serves as a reference compound in drug development research, particularly in the development of new NSAIDs and other anti-inflammatory agents. Its unique properties, such as lower ulcerogenic action and excellent gastric tolerability, make it a valuable model for researchers to study and improve upon in the quest for safer and more effective medications.
Originator
Sigma Tau (Italy)
Check Digit Verification of cas no
The CAS Registry Mumber 87344-06-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,3,4 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 87344-06:
(7*8)+(6*7)+(5*3)+(4*4)+(3*4)+(2*0)+(1*6)=147
147 % 10 = 7
So 87344-06-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)
87344-06-7Relevant articles and documents
Synthesis and process optimization of amtolmetin: An antiinflammatory agent
Reddy, Lekkala Amarnath,Chakraborty, Saurya,Swapna, Rodda,Bhalerao, Dinesh,Malakondaiah, Golla China,Ravikumar, Mylavarapu,Kumar, Abhijeet,Reddy, Gade Srinivas,Naram, Jyothirmayi,Dwivedi, Namrata,Roy, Arnab,Himabindu, Vurimidi,Babu, Bangaru,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 362 - 368 (2011/03/21)
Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf-Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.
