87344-05-6 Usage
General Description
Tolmetin glycinamide is a prodrug form of the nonsteroidal anti-inflammatory drug tolmetin, which is used to reduce pain, inflammation, and fever. When ingested, tolmetin glycinamide is converted into its active form tolmetin in the body. Tolmetin works by inhibiting the production of prostaglandins, which are naturally occurring chemicals in the body that cause pain and inflammation. This medication is typically used to treat conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is available in oral formulations and is generally well-tolerated, but may have potential side effects such as stomach irritation, kidney problems, and increased risk of cardiovascular events.
Check Digit Verification of cas no
The CAS Registry Mumber 87344-05-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,3,4 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 87344-05:
(7*8)+(6*7)+(5*3)+(4*4)+(3*4)+(2*0)+(1*5)=146
146 % 10 = 6
So 87344-05-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H18N2O4/c1-11-3-5-12(6-4-11)17(23)14-8-7-13(19(14)2)9-15(20)18-10-16(21)22/h3-8H,9-10H2,1-2H3,(H,18,20)(H,21,22)
87344-05-6Relevant articles and documents
Synthesis and process optimization of amtolmetin: An antiinflammatory agent
Reddy, Lekkala Amarnath,Chakraborty, Saurya,Swapna, Rodda,Bhalerao, Dinesh,Malakondaiah, Golla China,Ravikumar, Mylavarapu,Kumar, Abhijeet,Reddy, Gade Srinivas,Naram, Jyothirmayi,Dwivedi, Namrata,Roy, Arnab,Himabindu, Vurimidi,Babu, Bangaru,Bhattacharya, Apurba,Bandichhor, Rakeshwar
, p. 362 - 368 (2011/03/21)
Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf-Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.
