871249-25-1

Basic information

• Product Name: 23-O-acetylsilibinin
• Synonyms: 23-O-acetylsilibinin
• CAS NO: 871249-25-1
• Molecular Weight: 524.481
• Mol File: 871249-25-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 23-O-acetylsilibinin(CAS DataBase Reference)
• NIST Chemistry Reference: 23-O-acetylsilibinin(871249-25-1)
• EPA Substance Registry System: 23-O-acetylsilibinin(871249-25-1)

Safety Data

• Hazardous Substances Data: 871249-25-1(Hazardous Substances Data)

Upstream product

• 802918-57-6 silybin 
• 108-24-7 acetic anhydride 

Downstream Products

• 1220986-69-5 23-O-acetylsilybin A 
• 1220986-70-8 23-O-acetylsilybin B 
• 22888-70-6 silybin B 
• 22888-70-6 silibinin 
• 51419-48-8 hydnocarpin D 

Relevant articles and documents

Enzymatic kinetic resolution of silybin diastereoisomers

In nature, the flavonolignan silybin (1) occurs as a mixture of two diastereomers, silybin A and silybin B, which in a number of biological assays exhibit different activities. A library of hydrolases (lipases, esterases, and proteases) was tested for separating the silybin A and B diastereomers by selective transesterification or by stereoselective alcoholysis of 23-O-acetylsilybin (2). Novozym 435 proved to be the most suitable enzyme for the preparative production of both optically pure silybins A and B by enzymatic discrimination. Gram amounts of the optically pure substances can be produced within one week, and the new method is robust and readily scalable to tens of grams.