802918-57-6

Basic information

• Product Name: Silybin
• Synonyms: Silybin A,B (Mixture)
• CAS NO: 802918-57-6
• Molecular Formula: C₂₅H₂₂O₁₀
• Molecular Weight: 482.43618
• EINECS: 245-302-5
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
• Mol File: 802918-57-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 152-153°C
• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Acetone (Sparingly, Sonicated, Heated), DMSO (Slightly), Methanol (Slightly, Hea
• CAS DataBase Reference: Silybin(CAS DataBase Reference)
• NIST Chemistry Reference: Silybin(802918-57-6)
• EPA Substance Registry System: Silybin(802918-57-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: DJ2981770
• Hazardous Substances Data: 802918-57-6(Hazardous Substances Data)

Usage

Chemical Properties

Beige Solid

Uses

Hepatoprotectant. In nature, the flavonolignan Silybin occurs as a mixture of two diastereomers, Silybin A and Silybin B.

General Description

Produced and qualified by HWI pharma services GmbH.Exact content by quantitative NMR can be found on the certificate.

Upstream product

• 1220982-32-0 23-O-butyrylsilybin 
• 1220982-33-1 23-O-octanoylsilybin 

Downstream Products

• 142758-98-3 Dehydrosilybin 
• 802918-28-1 2-(2-{[(tert-butyldimethylsilyl)oxy]methyl}-3-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1,4-benzodioxin-6-yl)-3,5,7-trihydroxychroman-4-one 
• 1220986-69-5 23-O-acetylsilybin A 
• 1220986-70-8 23-O-acetylsilybin B 
• 871249-25-1 23-O-acetylsilibinin 
• 1220982-32-0 23-O-butyrylsilybin 
• 1220982-33-1 23-O-octanoylsilybin 
• 1326344-95-9 C₂₅H₂₂O₁₃S 
• 1326308-21-7 C₃₁H₂₆NO₁₅P 
• 1326308-06-8 23-azide-silybin 
• 1326308-07-9 23-amine-silybin 
• 1326308-08-0 sodium silybin-23-O-(4-nitrophenyl)-phosphate 
• 1326308-16-0 23-O-(4,4’-dimethoxytriphenylmethyl)silibinin 
• 1326308-17-1 3,5,7,20-O-tetra-acetyl-23-O-(4,4'-dimethoxytriphenylmethyl)-silybin 

Relevant articles and documents

Enzymatic kinetic resolution of silybin diastereoisomers

In nature, the flavonolignan silybin (1) occurs as a mixture of two diastereomers, silybin A and silybin B, which in a number of biological assays exhibit different activities. A library of hydrolases (lipases, esterases, and proteases) was tested for separating the silybin A and B diastereomers by selective transesterification or by stereoselective alcoholysis of 23-O-acetylsilybin (2). Novozym 435 proved to be the most suitable enzyme for the preparative production of both optically pure silybins A and B by enzymatic discrimination. Gram amounts of the optically pure substances can be produced within one week, and the new method is robust and readily scalable to tens of grams.