86708-67-0 Usage
Description
Ethyl (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate, also known as Ethyl 9-cis-retinoate, is a derivative of 9-cis-Retinoic Acid (R245000). It is an endogenous retinoic acid isomer that can bind to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). As a biologically active ligand for members of the RAR and RXR subfamilies, it plays a critical role in regulating retinoid-responsive pathways.
Uses
Used in Pharmaceutical Industry:
Ethyl 9-cis-retinoate is used as a biologically active ligand for members of the RAR and RXR subfamilies. Its ability to bind to these receptors implies that it may play a critical role in regulating retinoid-responsive pathways, making it a potential candidate for the development of pharmaceuticals targeting these pathways.
Used in Research Applications:
Ethyl 9-cis-retinoate is used as a research tool to study the effects of retinoic acid isomers on retinoid-responsive pathways. Its ability to bind to both RAR and RXR receptors makes it a valuable compound for investigating the mechanisms of action and potential therapeutic applications of these receptors in various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 86708-67-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,7,0 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 86708-67:
(7*8)+(6*6)+(5*7)+(4*0)+(3*8)+(2*6)+(1*7)=170
170 % 10 = 0
So 86708-67-0 is a valid CAS Registry Number.
86708-67-0Relevant articles and documents
METHOD FOR SYNTHESIS OF 9-CIS-BETA-CAROTENE AND FORMULATIONS THEREOF
-
Paragraph 0056-0057, (2017/12/29)
The present invention relates to a method for total chemical synthesis of 9-cis-β-carotene (9CBC), and further provides stable formulations thereof.
Caesium fluoride-promoted Stille coupling reaction: An efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block
Okitsu, Takashi,Iwatsuka, Kinya,Wada, Akimori
supporting information; experimental part, p. 6330 - 6332 (2009/04/13)
A highly efficient and rapid total synthesis of 9Z-retinoic acid was accomplished by caesium fluoride-promoted Stille coupling reaction; using a common building block, 9Z-retinoic acid analogues were also prepared by the same method without isomerisation of the Z-double bond. The Royal Society of Chemistry 2008.
Stereocontrolled synthesis of 13-substituted retinoic acids by palladium-catalyzed coupling reaction of alkenyl stannane with vinyl triflate
Wada,Fukunaga,Ito
, p. 800 - 802 (2007/10/03)
A novel method for the stereoselective synthesis of all-E-, 13Z- and 9Z- retionic acid esters was developed by palladium-catalyzed cross coupling reactions of tetraenyl stannanes with E- or Z-vinyl triflates in good yields. Applying this methodology, 13-substituted all-E- and 9Z- retinoic acids were prepared in satisfactory yields.
