65613-01-6Relevant articles and documents
Synthesis and antibacterial activity of some 5,5'-(1,4-phenylene)-bis-1,3, 4-oxadiazole and bis-1,2,4-triazole derivatives as precursors of new S-nucleosides
Datoussaid, Yazid,Othman, Adil A.,Kirsch, Gilbert
, p. 30 - 35 (2012/06/04)
Five compounds, namely 5,5'-benzene-1,4-diylbis(1,3,4-oxadiazole-2-thiol)6 and 5,5'-benzene-1,4-diylbis(1H-1,2,4-triazole-3-thiol) 7a and its derivatives 7b-d were synthesized. Two related S-nucleosides 9 and 10 have been prepared from 6 and 7a. Some of these synthesized compounds were tested in vitro by spotting on Mueller Hinton Agar medium against some Gram-positive bacteria, Staphylococcus aureus and Enterococcus faecalis and three Gram-negative bacteria Escherichia coli, Pseudomonasaeruginosa, Pseudomonas fluorescens and compared with the known antibiotics cephalosporin (cefotaxim) and gentamycin. Compound 6 showed significant inhibitory activity against Gram-positive E. faecalis and Gram-negative E. coli bacteria while the others have shown variable inhibition activity.
