65548-02-9

Basic information

• Product Name: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE
• Synonyms: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE;ETHYL CYANO(2-NITROPHENYL)ACETATE;Cyano(2-nitrophenyl)acetic Acid Ethyl Ester;α-Cyano-2-nitro-benzeneacetic Acid Ethyl Ester;ETHYL CYANO(2-NITROPHENYL)ACETATE(WX191716)
• CAS NO: 65548-02-9
• Molecular Formula: C₁₁H₁₀N₂O₄
• Molecular Weight: 234.21
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 65548-02-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 49-51°C
• Boiling Point: 402°C at 760 mmHg
• Flash Point: 196.9°C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 1.13E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE(65548-02-9)
• EPA Substance Registry System: ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE(65548-02-9)

Safety Data

• Hazardous Substances Data: 65548-02-9(Hazardous Substances Data)

Usage

Description

ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE, with the chemical name Ethyl Cyano(2-nitrophenyl)acetate and CAS number 65548-02-9, is an organic compound that plays a significant role in various chemical reactions and processes. Its unique molecular structure, featuring a cyano group and a nitrophenyl group, allows it to participate in a range of organic synthesis applications.

Uses

Used in Organic Synthesis:
ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE is used as a synthetic intermediate for the production of various organic compounds. Its reactivity and functional groups enable it to be a key component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE is used as a building block for the development of new drugs. Its ability to form diverse chemical entities makes it valuable in the creation of novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE also finds application in the agrochemical sector, where it serves as a precursor for the synthesis of pesticides and other crop protection agents. Its involvement in the development of these products contributes to enhancing crop yields and ensuring food security.
Used in Specialty Chemicals:
In the specialty chemicals market, ETHYL 2-CYANO-2-(2-NITROPHENYL)ACETATE is utilized as a raw material for the production of various high-value chemicals. Its versatility in chemical reactions allows it to be a crucial component in the synthesis of dyes, fragrances, and other specialty products.

InChI:InChI=1/C11H10N2O4/c1-2-17-11(14)9(7-12)8-5-3-4-6-10(8)13(15)16/h3-6,9H,2H2,1H3/t9-/m0/s1

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 609-73-4 o-nitroiodobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 577-19-5 2-nitrophenyl bromide 
• 1493-27-2 ortho-nitrofluorobenzene 
• 528-29-0 1,2-Dinitrobenzene 

Downstream Products

• 344331-74-4 (2-Amino-phenyl)-cyano-acetic acid ethyl ester 
• 1432508-53-6 N-hydroxy-4-((4-oxo-3,4-dihydropyrimido[4,5-b]indol-9-yl)methyl)benzamide 
• 1432509-70-0 methyl 4-((4-oxo-3,4-dihydropyrimido[4,5-b]indol-9-yl)methyl)benzoate 
• 1403589-33-2 4-(furan-2-yl)-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-9H-pyrimido[4,5-b]indole 
• 1403589-26-3 4-chloro-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-pyrimido[4,5-b]indole 
• 5719-08-4 4-chloro-1H-pyrimido[4,5-b]indole 
• 335605-43-1 ethyl 2-(2-nitrophenyl)-2-oxoacetate 
• 610-66-2 2-nitro-benzeneacetonitrile 
• 141135-81-1 1-Hydroxy-3-cyano-2-(4-trifluoromethylphenyl)indole 
• 88975-74-0 3-Benzoyl-1-[2-(cyano-methyl-methyl)-phenyl]-1-methyl-thiourea 
• 88975-59-1 1-Benzoyl-3-[2-(cyano-methyl-methyl)-phenyl]-thiourea 
• 88975-79-5 2-<2-(N-methyl-N-thiazol-2-ylamino)phenyl>propionic acid 
• 88975-97-7 2-<2-(2-thiazolyloxy)phenyl>propionic acid 
• 88975-49-9 2-<2-(2-thiazolylamino)phenyl>propionic acid 

Relevant articles and documents

Formal Total Synthesis of (±)-Strictamine by [2,3]-Sigmatropic Stevens Rearrangements

To date, more than 100 congeners of the akuammiline alkaloid family have been isolated. Their signature structural element is a methanoquinolizidine moiety, a cage-like scaffold structurally related to adamantane. The structural variations of the family members originate from oxidative processes that mostly trigger rearrangements of the methanoquinolizidine motif. The family of the akuammiline alkaloids is best represented by strictamine. It bears the least functionalized carbon skeleton of all family members without lacking the signature structural motifs. Herein, we report the formal synthesis of strictamine through a Stevens [2,3]-sigmatropic rearrangement as a key step and the synthetic pitfalls related with its synthesis.

Formal total synthesis of (±)-strictamine-the [2,3]-Stevens rearrangement for construction of octahydro-2: H -2,8-methanoquinolizines

For decades, akuammiline alkaloids have attracted synthetic chemists due to their intriguing molecular architecture. Among the different structural elements embedded in their carboskeleton, the methanoquinolizidine system constitutes the signature structu

HYDROXAMATE DERIVATIVES FOR HDAC INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THEREOF

The present invention relates to a novel hydroxamate derivatives, more specifically, to novel hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC), isomers thereof, pharmaceutically acceptable salts thereof, hydrates or solvates thereof, use for preparing pharmaceutical compositions, pharmaceutical compositions comprising the same, treatment method using said composition, and a preparing method of novel hydroxamate derivatives. The novel selective hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC) compositions can be used for treatment of inflammatory disease, rheumatoid arthritis, or degenerative disease.