65408-91-5

Basic information

• Product Name: Altholactone
• Synonyms: Altholactone;(+)-Goniothalenol;Goniothalenol
• CAS NO: 65408-91-5
• Molecular Formula: C₁₃H₁₂O₄
• Molecular Weight: 232.23198
• Mol File: 65408-91-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 108-109 °C(Solv: ethanol (64-17-5); benzene (71-43-2))
• Boiling Point: 490.4°Cat760mmHg
• Flash Point: 196.1°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 1.97E-10mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: ?20°C
• PKA: 12.82±0.40(Predicted)
• CAS DataBase Reference: Altholactone(CAS DataBase Reference)
• NIST Chemistry Reference: Altholactone(65408-91-5)
• EPA Substance Registry System: Altholactone(65408-91-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 65408-91-5(Hazardous Substances Data)

Usage

General Description

Altholactone is a natural chemical compound found in the roots of licorice plants. It belongs to the class of compounds known as flavonoids, which are known for their potent antioxidant and anti-inflammatory properties. Altholactone has been studied for its potential therapeutic effects, including its ability to inhibit the growth of cancer cells and reduce inflammation in the body. It has also been investigated for its antimicrobial and antiviral activities. Overall, altholactone shows promise as a bioactive compound with potential health benefits, but further research is needed to fully understand its mechanisms of action and potential applications in medicine.

InChI:InChI=1/C13H12O4/c14-10-7-6-9-13(17-10)11(15)12(16-9)8-4-2-1-3-5-8/h1-7,9,11-13,15H/t9-,11+,12+,13+/m0/s1

Upstream product

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• 302348-89-6 (5S)-5-tert-butyldimethylsilanyloxy-(6S)-6-trans-styryl-5,6-dihydro-pyran-2-one 
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• 302348-83-0 (S)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2H-pyran-2,5(6H)-dione 

Downstream Products

• 65408-91-5 (2S,3R)-3-Hydroxy-2-phenyl-2,3,3a,7a-tetrahydro-furo[3,2-b]pyran-5-one 
• 199326-63-1 (-)-etharvensin 
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• 242150-07-8 Acetic acid (2R,3R,3aR,6S,7R,7aS)-6,7-dihydroxy-5-oxo-2-phenyl-hexahydro-furo[3,2-b]pyran-3-yl ester 
• 219987-39-0 (+)-alumheptolide-A 

Relevant articles and documents

Synthesis of (+)-altholactone, (+)-7-epi-altholactone, (?)-etharvensin, and (+)-alumheptolide-A using Pd-catalyzed carbonylation

Syntheses of (+)-altholactone isolated from Goniothalamus giganteus and its C-7 epimer (+)-7-epi-altholactone, (?)-etharvensin and (+)-alumheptolide-A were achieved. The lactone ring of these compounds was constructed using Pd-catalyzed carbonylation.

Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone

We describe a concise synthesis of (+)-isoaltholactone via a Au-catalysed cyclisation of a monoallylic diol to form the tetrahydrofuranyl ring. Analogous cyclisations show that the stereochemical outcome is dictated by the stereochemistry of the diol substrate.

Stereoselective synthesis of (+)-goniodiol, (+)-goniotriol, (-)-goniofupyrone, and (+)-altholactone using a catalytic asymmetric hetero-Diels-Alder/allylboration approach

The stereoselective total synthesis of several members of the styryllactone family was achieved efficiently from common intermediate 8, prepared by a catalytic asymmetric inverse-electron-demand hetero-Diels-Alder/allylboration sequence. The transformatio