62327-21-3 Usage
Description
tert-Butyl O,O-dimethylphosphonoacetate is an organic compound that serves as a versatile reagent and intermediate in the synthesis of various chemical compounds and pharmaceuticals. It is characterized by its phosphonoacetate group, which is a key functional group in many biologically active molecules.
Uses
Used in Pharmaceutical Industry:
tert-Butyl O,O-dimethylphosphonoacetate is used as a reactant for the preparation of phosphonate terminated PPH dendrimers, which have potential applications as anti-HIV-1 agents. These dendrimers can help inhibit the replication of the HIV-1 virus, offering a promising approach to combat the disease.
Used in Organic Synthesis:
tert-Butyl O,O-dimethylphosphonoacetate is used as a reactant for the preparation of monodehydro diketopiperazines from ketoacyl amino acid amides via acid-catalyzed cyclization. This reaction is an important step in the synthesis of various natural products and pharmaceuticals.
Used in Organic Chemistry:
tert-Butyl O,O-dimethylphosphonoacetate is used as a reactant for the preparation of α,β-unsaturated esters, which are useful in the guanidine-catalyzed oxa-Michael addition. This reaction is a key step in the synthesis of various complex organic molecules.
Used in Antibacterial Agents:
tert-Butyl O,O-dimethylphosphonoacetate is used as a reactant for the preparation of myxopyronin B and desmethyl myxopyronin B analogs, which exhibit antibacterial activity and inhibitory activity against bacterial RNA polymerase. These compounds can be used as potential antibacterial agents in the development of new antibiotics.
Used in Organic Reactions:
tert-Butyl O,O-dimethylphosphonoacetate is used as a reactant in allylation and subsequent ring-closing metathesis in the presence of Grubbs' catalyst or intramolecular rhodium-catalyzed cyclopropanation reactions. These reactions are important for the synthesis of various complex organic molecules and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 62327-21-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,3,2 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 62327-21:
(7*6)+(6*2)+(5*3)+(4*2)+(3*7)+(2*2)+(1*1)=103
103 % 10 = 3
So 62327-21-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H17O5P/c1-8(2,3)13-7(9)6-14(10,11-4)12-5/h6H2,1-5H3
62327-21-3Relevant articles and documents
CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190
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Page/Page column 29; 161-162, (2009/07/25)
DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro- drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is =O; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH 2) r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.
