570-24-1Relevant articles and documents
Method for synthesizing 2-amino-3-nitrotoluene
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Paragraph 0015; 0020-0025, (2021/01/11)
The invention provides a method for synthesizing 2-amino-3-nitrotoluene. The method comprises the following steps: mixing raw materials 4-amino-3-methylbenzenesulfonic acid, zinc oxide and acetic acid, reacting at 25-100 DEG C for 4 hours, carrying out diatomite filtration, cooling the filtrate to 0-12 DEG C, dropwisely adding concentrated nitric acid, controlling the system temperature at 0-12 DEG C, reacting for 30 minutes while keeping the temperature after the drop-by-drop addition is finished, pouring the obtained reaction solution into ice water, and performing suction filtration to obtain a solid, namely a nitrification product; and mixing the nitrification product with concentrated hydrochloric acid, heating to reflux and hydrolyze for 1 h, and then carrying out aftertreatment on the reaction solution to obtain the product 2-amino-3-nitrotoluene. According to the invention, the reaction selectivity is improved, the post-treatment method is optimized, the environmental protection pressure is reduced, the environmental pollution is avoided, and the yield and purity of the target product are effectively improved.
Selectivity of the complexation reactions of four regioisomeric methylcamphorquinoxaline ligands with gold(III): X-ray, NMR and DFT investigations
Gli?i?, Biljana D.,Hoffmann, Marcin,Warzajtis, Beata,Gen?i?, Marija S.,Blagojevi?, Polina D.,Radulovi?, Niko S.,Rychlewska, Urszula,Djuran, Milo? I.
, p. 137 - 149 (2016/01/15)
Reported are the synthesis, spectral and structural characteristics of new quinoxaline-related regioisomeric ligands L1-L4 (1,x,11,11-tetramethyl-1,2,3,4-tetrahydro-1,4-methanophenazine, x = 7, 8, 9 and 6, respectively) and their mononuclear Au(III) complexes (1-4). Fusion of the camphor moiety to the quinoxaline core made two N-atoms of quinoxaline nonequivalent while the introduction of a methyl-substituent at positions 6-9 enabled a tuning of coordination properties of L1-L4. Gold(III) complexes 1-4 and ligands L1-L4 have been studied in detailed by 1D and 2D NMR and the structures of 1-4 have been determined by X-ray crystallography. The results of these analyses revealed a regiospecific coordination of Au(III) to the sterically less hindered N-5 atom (spatially close to the non-substituted bridgehead carbon) of L1-L3, and to N-10 (spatially close to the methyl-substituted bridgehead carbon) of L4. The results of DFT calculations shed light on disparate coordination modes of L1-L4 toward the AuCl3 fragment and explain formation of single coordination products in high yield.
SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS
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Page/Page column 124, (2010/11/18)
The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).