544-70-7

Basic information

• Product Name: (9Z,11Z)-octadeca-9,11-dienoic acid
• Synonyms: 9,11-octadecadienoic acid, (9Z,11Z)-
• CAS NO: 544-70-7
• Molecular Formula: C₁₈H₃₂O₂
• Molecular Weight: 280.4455
• Mol File: 544-70-7.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 381.6°C at 760 mmHg
• Flash Point: 278.5°C
• Density: 0.911g/cm³
• Vapor Pressure: 7.01E-07mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (9Z,11Z)-octadeca-9,11-dienoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (9Z,11Z)-octadeca-9,11-dienoic acid(544-70-7)
• EPA Substance Registry System: (9Z,11Z)-octadeca-9,11-dienoic acid(544-70-7)

Safety Data

• Hazardous Substances Data: 544-70-7(Hazardous Substances Data)

Usage

Description

(9Z,11Z)-octadeca-9,11-dienoic acid, also known as 9(Z),11(Z)-conjugated linoleic acid, is an isomer of linoleic acid that has been found in milk from cows and other animals. It is a conjugated linoleic acid, a compound that has been reported to exhibit anticarcinogenic activity. This acid is characterized by its cytotoxic properties against Caco-2 human colon cancer cells and its ability to induce changes in the miRNA profile, which is involved in apoptosis.

Uses

Used in Anticancer Applications:
(9Z,11Z)-octadeca-9,11-dienoic acid is used as an anticancer agent for its cytotoxic effects on Caco-2 human colon cancer cells. It modulates the miRNA profile, including the upregulation of hsa-miR-146a-5p and downregulation of hsa-miR-32-5p, which play a role in apoptosis.
Used in the Beauty Products Industry:
(9Z,11Z)-octadeca-9,11-dienoic acid is used as an ingredient in beauty products for its anti-inflammatory, acne reductive, and moisture-retentive properties when applied topically on the skin. Its beneficial effects on the skin make it popular in the beauty products industry.
Used in Pharmaceutical Research:
(9Z,11Z)-octadeca-9,11-dienoic acid is used as a subject of pharmaceutical research for its potential in developing novel drug delivery systems and enhancing therapeutic outcomes in cancer treatment.

Upstream product

• 56-23-5 tetrachloromethane 
• 60-33-3 linoleic acid 
• 111-46-6 diethylene glycol 
• 2462-85-3 linoleic acid methyl ester 
• 6114-22-3 9t,11t-octadecadienoic acid ethyl ester 
• 33128-27-7 octadeca-9,11-diynoic acid 
• 112-63-0 Methyl linoleate 
• 141-22-0 Ricinoleic acid 
• 119-61-9 benzophenone 
• 822-10-6 octadeca-9,11-dienoic acid methyl ester 
• 822-10-6 (9Z,11E)-methyl octadeca-9,11-dienoate 
• 8001-23-8 safflower oil 
• 544-70-7 cis-9,trans-11-octadecadienoic acid 
• 112-53-8 1-dodecyl alcohol 

Downstream Products

• 544-70-7 trans-9,trans-11-octadecadienoic acid 
• 87-93-4 9r_F,10t_F,11r'_F,12t'_F-tetrahydroxy-octadecanoic acid 
• 903581-73-7 octadeca-9t,11t-dienoyl chloride 
• 872-23-1 (9E,11Z)-Octadeca-9,11-dienoic acid 
• 6114-22-3 9t,11t-octadecadienoic acid ethyl ester 
• 822-10-6 octadeca-9,11-dienoic acid methyl ester 
• 6935-55-3 8-[7-hexyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydroisobenzofuran-4-yl]octanoic acid 

Relevant articles and documents

Revealing ruthenium and basicity synergetic effects in Ru-MgAl catalysts for isomerization of linoleic acid to conjugated linoleic acid

Ru-MgAl catalysts were prepared by co-precipitation at different pH values (x = 7-12), with the aims of investigating the effect of pH on their catalytic performance for isomerization of linoleic acid to conjugated linoleic acid and of understanding the relationship of basicity site and ruthenium activity site. The results showed that strong basicity and highly dispersed ruthenium may be the active sites for linoleic acid isomerization. Only if all three conditions, i.e., high Ru dispersion, appropriate SMSI effect and high number of strong basicity sites, are fulfilled can highly effective active sites be formed for the isomerization of linoleic acid to conjugated linoleic acid. A possible reaction mechanism for the isomerization was also proposed.

Synergetic effect of ruthenium and basicity sites in the Ru-MgAl catalyst for hydrogen-free production of conjugated linoleic acids

A series of Ru-MgAl composite oxide catalysts prepared by calcining the ruthenium grafted hydrotalcite-like precursor at various temperatures were used in the hydrogen-free production of conjugated linoleic acid. The effect of calcination temperature on the textural, base and catalytic properties of the materials was investigated. Results indicated that the Ru-MgAl composite oxides calcined at 450 °C showed high activity, namely, CLA productivity, CLA production rate and TOF up to 1.52 g CLA g (CLA) L-1 (solvent) min-1, 284 g (CLA) g-1 (Ru) h-1 and 102.6 mol (LA converted) mol-1 (Ru) h-1. Moreover, the biologically active CLA isomers, cis-9, trans-11, trans-10, cis-12 and trans-9, trans-11-CLA, were the main products, while almost no hydrogenated products were formed. Meanwhile, the role of ruthenium and basicity sites in the catalytic reaction has been studied. It was found that the basicity sites of the Ru-MgAl catalyst and the ruthenium activity sites seem to have a synergic effect on the catalytic reaction. The possible reaction mechanism for the isomerization was also proposed. This journal is

Method For The Production Of Conjugated Polyunsaturated Fatty Acids With Heterogenous Catalysts

The present invention relates to an improved process for the production of conjugated polyunsaturated fatty acids (PUFA), preferably conjugated linoleic acid (CLA), using finely dispersed heterogeneous metal catalysts on a mesoporous support, in the absence of Hg. The present invention also relates to a method to increase the large microporosity and (optionally) the small mesoporosity of a zeolite, thus obtaining a modified zeolite having a large and highly accessible internal surface.