506-26-3 Usage
Description
Gamma-Linolenic acid (GLA) is an omega-6 fatty acid primarily found in vegetable oils. It is known for its potential immune-regulating and anti-inflammatory effects, and is sold as a dietary supplement for treating inflammation and autoimmune diseases. GLA has a chemical structure with an 18-carbon chain and three cis double bonds, making it an isomer of alpha-linolenic acid, a polyunsaturated omega-3 fatty acid.
Uses
Used in Pharmaceutical Industry:
Gamma-Linolenic acid is used as an anti-inflammatory and immune-regulating agent for the treatment of various inflammation-related conditions and autoimmune diseases. It may also be used in the treatment of atopic eczema, although its efficacy is disputed.
Used in Analytical Chemistry:
GLA is used as an analytical standard in gas chromatography, which is a technique used to separate and analyze compounds that can be vaporized without decomposition.
Used in Nutritional Studies:
Gamma-Linolenic acid is used in nutritional studies regarding weight regain and as a possible tumor suppression agent. It is also used in research on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids.
Used in Food Industry:
GLA is found in various vegetable oils such as GLA safflower oil, evening primrose oil, blackcurrant seed oil, borage oil, and hemp seed oil. It is also present in edible hemp seeds, oats, barley, and spirulina. These sources can be used in the food industry to provide a dietary source of GLA for consumers.
Used in Genetically Modified Products:
GLA safflower oil, a novel concentrated form of GLA, is a genetically modified oil that has been available in commercial quantities since 2011. This oil contains 40% GLA, making it a valuable source for the production of GLA-rich products in the food and pharmaceutical industries.
History
GLA was first isolated from the seed oil of evening primrose. This herbal plant was grown by Native Americans to treat swelling in the body. In the 17th century, it was introduced to Europe and became a popular folk remedy, earning the name king's cure-all. in 1919, Heiduschka and Lüft extracted the oil from evening primrose seeds and described an unusual linolenic acid, which they name γ-. Later, the exact chemical structure was characterized by Riley. Although there are α- and γ- forms of linolenic acid, there is no β- form. One was once identified, but it turned out to be an artifact of the original analytical process.
Biochem/physiol Actions
Gamma-linolenate (C18:6,9,12) differs from α-linolenate (C18:9,12,15) in the positions of the double bonds.
references
[1] yagaloff k a, franco l, simko b, et al. essential fatty acids are antagonists of the leukotriene b4 receptor[j]. prostaglandins, leukotrienes and essential fatty acids, 1995, 52(5): 293-297.[2] crooks s w, stockley r a. leukotriene b4[j]. the international journal of biochemistry & cell biology, 1998, 30(2): 173-178.[3] tasset-cuevas i, fernández-bedmar z, lozano-baena m d, et al. protective effect of borage seed oil and gamma linolenic acid on dna: in vivo and in vitro studies[j]. plos one, 2013, 8(2): e56986.[4] jamal g a, carmichael h. the effect of γ‐linolenic acid on human diabetic peripheral neuropathy: a double‐blind placebo‐controlled trial[j]. diabetic medicine, 1990, 7(4): 319-323.[5] andreassi m, forleo p, dilohjo a, et al. efficacy of γ-linolenic acid in the treatment of patients with atopic dermatitis[j]. journal of international medical research, 1997, 25(5): 266-274.
Check Digit Verification of cas no
The CAS Registry Mumber 506-26-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 506-26:
(5*5)+(4*0)+(3*6)+(2*2)+(1*6)=53
53 % 10 = 3
So 506-26-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-
506-26-3Relevant articles and documents
PROCESS FOR INCREASING THE STABILITY OF A COMPOSITION COMPRISING POLYUNSATURATED OMEGA-6 FATTY ACIDS
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Page/Page column 15; 16, (2016/07/27)
The present invention relates to processes for increasing the stability of compositions comprising polyunsaturated omega-6 fatty acids against oxidation. The processes comprise the following steps: (i) providing a starting composition comprising at least one polyunsaturated omega-6 fatty acid component; (ii) providing a lysine composition; (iii) admixing aqueous, aqueous-alcoholic or alcoholic solutions of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition comprising at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-6 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC 5 wt%, SC 3 wt%, SC 1 wt%, SC 0.5 wt%. Compositions obtainable by such spray drying processes and use of such compositions for the manufacture of food, nutritional and pharmaceutical products are further comprised by the present invention.
SOYBEAN VARIETY A1024175
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Page/Page column, (2013/03/26)
The invention relates to the soybean variety designated A1024175. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024175. Also provided by the invention are tissue cultures of the soybean variety A1024175 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024175 with itself or another soybean variety and plants produced by such methods.
SOYBEAN VARIETY A1025921
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Page/Page column, (2013/03/26)
The invention relates to the soybean variety designated A1025921. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1025921. Also provided by the invention are tissue cultures of the soybean variety A1025921 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1025921 with itself or another soybean variety and plants produced by such methods.