24149-05-1Relevant articles and documents
PROCESS FOR PREPARING AND PURIFYING FATTY ACIDS
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Page/Page column 16, (2011/08/21)
There is provided a process for purifying a fatty acid, which process comprises reacting a fatty acid with a lithium salt in a first solution and under conditions to allow formation of a precipitate of a lithium salt of the fatty acid; isolating the precipitate; dissolving the precipitate in a second solution followed by separation of the organic and aqueous layers so formed; and evaporating the organic layer to isolate the purified fatty acid. There is also provided a process for increasing the length of a fatty acid, and the use of a lithium salt to purify a fatty acid.
Optimization of synthetic conditions for the preparation of dihomo-γ-linolenic acid from γ-linolenic acid
Xue, Gang,Liu, Fengxia,Wang, Ying,Huang, Kaixun
experimental part, p. 77 - 82 (2010/03/31)
Orthogonal experiments were employed to optimize the correlated parameters of reduction, sulfonation, substitution and hydrolysis. These reactions were used to convert γ-linolenic acids into dihomo-γ-linolenic acids (DGLA). For the reduction, the best rea
Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and Cdc25B inhibition
Sodeoka,Sampe,Kojima,Baba,Usui,Ueda,Osada
, p. 3216 - 3222 (2007/10/03)
Selective inhibitors of protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases (DSPs) are expected to be useful tools for clarifying the biological functions of the PTPs themselves and also to be candidates for novel therapeutics. We planned a library approach for the identification of PTP/DSP inhibitors in which 3-acyltetronic acid is used as a "core" phosphate mimic. A series of novel tetronic acid derivatives were synthesized and evaluated as inhibitors of the dual-specificity protein phosphatases VHR and cdc25B. Several compounds are found to be potent inhibitors of cdc25B, which is a key enzyme for cell-cycle progression. The promising results described herein strongly indicated that this tetronic acid library is potent as a library focused on the PTP/DSP-selective inhibitor.