4385-35-7 Usage
Description
3-Isochromanone is an organic compound that has been isolated from the fungus Nigrospora sp. PSU-F12. It is known for its chemical properties, which include forming lamellae. An improved Knoevenagel condensation of 3-isochromanone with aromatic aldehydes has been achieved through microwave irradiation on solid supports in the presence of various catalysts. Additionally, the synthesis of 3-isochromanone via Beayer-Villiger rearrangement has been reported.
Uses
Used in Pharmaceutical Industry:
3-Isochromanone is used as a starting reagent for the synthesis of BDPBI (7-bromo-1,4-dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)2H-isoquinolin-3-one dihydrochloride), which is a compound of interest in the pharmaceutical industry due to its potential applications in drug development and therapeutics.
Used in Chemical Synthesis:
3-Isochromanone serves as a valuable intermediate in the synthesis of various organic compounds. Its improved Knoevenagel condensation with aromatic aldehydes, achieved through microwave irradiation on solid supports and the presence of catalysts, highlights its utility in chemical synthesis processes.
Used in Research and Development:
The synthesis of 3-isochromanone via Beayer-Villiger rearrangement has been reported, making it a subject of interest for researchers and scientists working on new methods and techniques in organic chemistry. 3-ISOCHROMANONE's unique properties and synthesis pathways contribute to the advancement of knowledge in the field.
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 4193, 1980 DOI: 10.1021/ja00532a034Tetrahedron Letters, 36, p. 8123, 1995 DOI: 10.1016/0040-4039(95)01692-B
Check Digit Verification of cas no
The CAS Registry Mumber 4385-35-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,8 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4385-35:
(6*4)+(5*3)+(4*8)+(3*5)+(2*3)+(1*5)=97
97 % 10 = 7
So 4385-35-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H8O2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-4H,5-6H2
4385-35-7Relevant articles and documents
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Spangler,Hokim
, p. 107 (1973)
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Visible Light-Promoted Magnesium, Iron, and Nickel Catalysis Enabling C(sp3)-H Lactonization of 2-Alkylbenzoic Acids
Li, Sasa,Su, Mincong,Sun, Jie,Hu, Kunjun,Jin, Jian
supporting information, p. 5842 - 5847 (2021/07/31)
A mild and practical C(sp3)-H lactonization protocol has been achieved by merging photocatalysis and magnesium (iron, nickel) catalysis. A diverse range of 2-alkylbenzoic acids with a variety of substitution patterns could be transformed into the corresponding phthalide products. Based on the mechanistic experimentation and reported prior studies, a possible mechanism for the benzylic oxidative lactonization reaction was proposed with the hypothetic photoactive ternary complex formed between the 2-alkylbenzoic acid substrate, magnesium ion, and bromate anion.
Synthesis method of 3-isochromanone
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, (2021/01/04)
The invention belongs to the technical field of synthesis of organic intermediates, and particularly relates to a synthesis method of 3-isochromanone, which comprises the following steps of: (1) synthesizing o-methyl benzyl chloride by using o-xylene as a raw material; (2) synthesizing o-methyl benzyl cyanide by taking o-methyl benzyl chloride as a raw material; (3) synthesizing sodium o-methyl phenylacetate by taking o-methyl benzyl cyanide as a raw material; (4) synthesizing o-methyl phenylacetic acid by taking sodium o-methyl phenylacetate as a raw material; (5) synthesizing 2-chloromethylphenylacetic acid by taking o-methyl phenylacetic acid as a raw material; and (6) synthesizing 3-isochromanone by taking 2-chloromethyl phenylacetic acid as a raw material. The synthesis method of 3-isochromanone has the advantages of simple reaction process, easily available raw materials, mild reaction conditions, high product yield, low production cost, high yield, high product purity, good quality, low production waste discharge amount and the like, the product purity is greater than or equal to 99.5%, the production yield is greater than or equal to 92%, and the product meets the use requirements of foreign high-end users.