361189-66-4 Usage
Description
Azido-PEG7-acid is an aqueous soluble PEG (polyethylene glycol) linker that features an azide group and a terminal carboxylic acid. This versatile molecule is designed to facilitate chemical reactions and modifications through its functional groups, making it a valuable component in various applications across different industries.
Uses
Used in Bioconjugation and Drug Development:
Azido-PEG7-acid is used as a bioconjugation agent for the attachment of biomolecules, such as proteins or peptides, to other molecules via stable amide bonds. The terminal carboxylic acid allows for the formation of these bonds with primary amine groups in the presence of activators like EDC or HATU. This property is particularly useful in the development of targeted drug delivery systems and the creation of bioconjugates for research purposes.
Used in Click Chemistry:
Azido-PEG7-acid is used as a Click Chemistry component for the formation of stable triazole linkages with alkyne, BCN, or DBCO groups. The azide group in Azido-PEG7-acid enables efficient and selective reactions, making it an ideal candidate for the synthesis of complex molecular structures and the development of novel biomaterials.
Used in Pharmaceutical and Diagnostic Applications:
Azido-PEG7-acid is used as a molecular building block in the pharmaceutical and diagnostic industries. Its ability to form stable bonds with a variety of molecules allows for the creation of new drug candidates, drug delivery systems, and diagnostic tools. The PEGylation of drugs and other biomolecules using Azido-PEG7-acid can improve their solubility, stability, and circulation time in the body, potentially enhancing their therapeutic efficacy.
Used in Material Science:
In the field of material science, Azido-PEG7-acid is used as a component in the development of novel biomaterials and coatings. The PEG linker provides flexibility and solubility, while the reactive groups enable the creation of complex, functionalized materials with tailored properties for specific applications, such as tissue engineering, drug delivery, or surface modification.
Overall, Azido-PEG7-acid is a versatile and valuable molecule with a wide range of applications across various industries, including bioconjugation, drug development, click chemistry, pharmaceuticals, diagnostics, and material science. Its unique properties and functional groups make it an essential tool for researchers and developers working on innovative solutions in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 361189-66-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,1,1,8 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 361189-66:
(8*3)+(7*6)+(6*1)+(5*1)+(4*8)+(3*9)+(2*6)+(1*6)=154
154 % 10 = 4
So 361189-66-4 is a valid CAS Registry Number.
361189-66-4Relevant articles and documents
SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
-
, (2017/08/07)
Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside
Tamura, Satoru,Inomata, Sho,Ebine, Makoto,Genji, Takahisa,Iwakura, Izumi,Mukai, Makoto,Shoji, Mitsuru,Sugai, Takeshi,Ueda, Minoru
supporting information, p. 188 - 193 (2013/02/23)
In methods employing molecular probes to explore the targets of bioactive small molecules, long or rigid linker moieties are thought to be critical factors for efficient tagging of target protein. We previously reported the synthesis of a jasmonate glucoside probe with a highly rigid linker consisting of a triazoyl-phenyl (TAzP) moiety, and this probe demonstrated effective target tagging. Here we compare the TAzP probe with other rigid or flexible probes with respect to target tagging efficiency, hydrophobic parameters, aqueous solubility, and dihedral angles around the biaryl linkage by a combination of empirical and calculation methods. The rigid biaryl linkage of the TAzP probe has a skewed conformation that influences its aqueous solubility. Such features that include rigidness and good aqueous solubility resulted in highly efficient target tagging. These findings provide a promising guideline toward designing of better linkers for improving molecular probe performance.
