343351-67-7

Basic information

• Product Name: NSC697923
• Synonyms: Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-;NSC697923;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;2-Nitro-5-tosylfuran;2-Nitro-5-(toluene-4-sulfonyl)-furan
• CAS NO: 343351-67-7
• Molecular Formula: C11H9NO5S
• Molecular Weight: 267.25786
• Product Categories: Inhibitors
• Mol File: 343351-67-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 443.8±40.0 °C(Predicted)
• Appearance: white to beige/
• Density: 1.416±0.06 g/cm3(Predicted)
• Storage Temp.: ?20°C
• Solubility: DMSO: soluble20mg/mL, clear
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• CAS DataBase Reference: NSC697923(CAS DataBase Reference)
• NIST Chemistry Reference: NSC697923(343351-67-7)
• EPA Substance Registry System: NSC697923(343351-67-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 343351-67-7(Hazardous Substances Data)

Usage

Description

NSC697923, also known as NSC-69723, is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. It is characterized by its ability to impede the formation of Ubc13 and inhibit NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells. NSC697923 acts via covalent bonding to the E2 active site thiol and is effective in inducing neuroblastoma cell death through the activation of p53 and JNK.

Uses

Used in Cancer Treatment:
NSC697923 is used as a therapeutic agent for the treatment of neuroblastoma, a type of cancer commonly imaged in the context of the nervous system. It exhibits potent cytotoxicity in a panel of neuroblastoma cell lines, effectively blocking their proliferation and survival.
Additionally, NSC697923 is used as a therapeutic agent for the treatment of diffuse large B-cell lymphoma (DLBCL), particularly the activated B cell-like (ABC-DLBCL) and germinal center B cell-like (GCB-DLBCL) subtypes. It inhibits the proliferation and survival of both ABC-DLBCL and GCB-DLBCL cell lines, as well as the survival of primary DLBCL cells.

References

1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668 2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427 3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718 4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079