NSC697923

Base Information

• Chemical Name: NSC697923
• CAS No.: 343351-67-7
• Molecular Formula: C11H9NO5S
• Molecular Weight: 267.25786
• Mol file: 343351-67-7.mol

Synonyms:Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-;NSC697923;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;2-Nitro-5-tosylfuran

Chemical Property of NSC697923

Chemical Property:

• Boiling Point: 443.8±40.0 °C(Predicted)
• PSA: 101.48000
• Density: 1.416±0.06 g/cm3(Predicted)
• LogP: 3.93300
• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble20mg/mL, clear

Purity/Quality:

98% min ^*data from raw suppliers

NSC697923 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Description: NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4
• Uses: NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).