2958-98-7

Basic information

• Product Name: 3-METHYLGUANINE
• Synonyms: 2-amino-3,7-dihydro-3-methyl-6H-purin-6-one;2-amino-3-methyl-7H-purin-6-one;2-Amino-6-hydroxy-3-methylpurine;2-Amino-3-methyl-3H-purin-6(7H)-one;2-azanyl-3-methyl-7H-purin-6-one;2-aMino-3-Methyl-6H-1$l^{2},3,7,9-purin-6-one;2-amino-3-methyl-3,9-dihydro-6H-purin-6-one
• CAS NO: 2958-98-7
• Molecular Formula: C₆H₇N₅O
• Molecular Weight: 165.15268
• EINECS: 220-988-9
• Mol File: 2958-98-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: ≥300 °C
• Boiling Point: 526.5 °C at 760 mmHg
• Flash Point: 272.2 °C
• Appearance: /
• Density: 1.83 g/cm³
• Vapor Pressure: 2.83E-17mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 3-METHYLGUANINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLGUANINE(2958-98-7)
• EPA Substance Registry System: 3-METHYLGUANINE(2958-98-7)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 2958-98-7(Hazardous Substances Data)

Usage

Description

3-Methylguanine, also known as N2-methylguanine, is a derivative of the nucleotide guanine. It is characterized by the presence of a methyl group at the 3rd position and an amino group at the 2nd position on the 3,9-dihydro-6H-purin-6-one structure. 3-METHYLGUANINE has been investigated for its potential as a purine antagonist, which may have implications in various biological and pharmaceutical applications.

Uses

Used in Pharmaceutical Applications:
3-Methylguanine is used as a purine antagonist for its potential role in modulating purine metabolism and interactions with purine receptors. This application is significant in the development of therapeutic strategies for various diseases and conditions that involve purine metabolism dysregulation.
Used in Research and Development:
3-Methylguanine serves as a valuable compound in the field of research and development, particularly in the study of nucleic acid chemistry, molecular biology, and drug discovery. Its unique structure and properties make it a useful tool for understanding the mechanisms of purine interactions and for designing new drugs targeting purine-related pathways.
Used in Biochemical Studies:
In biochemical studies, 3-Methylguanine is used as a reference compound to investigate the effects of methylation on the properties and functions of nucleobases and nucleotides. This helps researchers gain insights into the role of methylation in gene regulation, DNA repair, and other cellular processes.
Used in Cancer Research:
3-Methylguanine has been investigated for its potential role in cancer research, particularly in the context of purine metabolism and its impact on cancer cell growth and survival. As a purine antagonist, it may contribute to the development of novel therapeutic approaches for cancer treatment.
Used in Drug Design:
3-Methylguanine is utilized in drug design to create new molecules with specific biological activities. Its unique structure and potential as a purine antagonist make it an attractive starting point for the development of new drugs targeting purine-related pathways, which could be beneficial in treating various diseases and conditions.

InChI:InChI=1/C6H9N5O/c1-11-4-3(8-2-9-4)5(12)10-6(11)7/h2,6H,7H2,1H3,(H,8,9)(H,10,12)

Upstream product

• 68768-32-1 3-methylguanosine 
• 58160-46-6 2,6-diamino-1-methyl-5-nitroso-4-pyrimidone 
• 68768-32-1 3-methylguanosine 
• 30747-22-9 N²-acetyl-7-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)guanine 
• 68768-26-3 5-(methylamino)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carboxamide 
• 70230-72-7 5-(methylamino)-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide 
• 69265-28-7 5-(cyanomethylamino)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carboxamide 
• 76542-73-9 5-(N-cyanomethylamino)-1-β-D-ribofuranosylimidazole-4-carboxamide 
• 84321-38-0 2,6-diamino-1-methyl-4-pyrimidone hemihydrochloride 
• 40959-21-5 3-methyl-2-methylsulfanyl-7H-purin-6(3H)-one 
• 1130-04-7 2,5,6-triamino-1-methyl-4-pyrimidone sulfate 
• 77287-34-4 formamide 
• 52662-10-9 3,4-Dihydro-4,6-dimethyl-3-β-D-ribofuranosyl-9H-imidazo<1,2-a>purin-9-one 
• 20535-83-5 O-methylguanine 

Downstream Products

• 122775-72-8 1-Benzyl-2-chloro-4,6-dimethyl-7-((E)-3-methyl-but-1-enyl)-1,4-dihydro-imidazo[1,2-a]purin-9-one 
• 122775-72-8 1-Benzyl-2-chloro-4,6-dimethyl-7-((E)-3-methyl-but-1-enyl)-1,4-dihydro-imidazo[1,2-a]purin-9-one 
• 122805-01-0 C₃₇H₃₆N₁₀O₂ 
• 122775-68-2 bis(1-benzyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purin-2-yl)ketone 
• 122775-74-0 bis(1-benzyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purin-7-yl)methane 
• 122775-63-7 (+/-)-1-benzyl-1,4-dihydro-7-(2-isopropyl-5-methyl-1,3-dioxohexyl)-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one 
• 122775-67-1 1-benzyl-2-benzyloxycarbonyl-1,4-dihydro-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one 
• 122775-66-0 (+/-)-1-benzyl-1,4-dihydro-4,6-dimethyl-2-(1-hydroxy-3-methylbutyl)-9H-imidazo<1,2-a>purin-9-one 
• 122775-71-7 (+/-)-1-benzyl-2-chloro-7-(1-hydroxy-3-methylbutyl)wye 
• 122775-62-6 1-benzyl-1,4-dihydro-4,6-dimethyl-7-(3-methyl-2-oxobutyl)-9H-imidazo<1,2-a>purin-9-one 
• 122775-75-1 1-benzyl-2-chloro-5-(2,2-dimethyl-1-oxopropyl)-4--1H-imidazole 
• 122775-64-8 1-Benzyl-7-bromo-6-bromomethyl-4-methyl-1,4-dihydro-imidazo[1,2-a]purin-9-one 
• 122775-70-6 1-benzyl-7-bromo-2-chlorowye 
• 122775-61-5 1-benzyl-7-(1-oxopropyl)wye 

Relevant articles and documents

A novel route to 3-methylguanosine by chemical degradation of wyosine

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Facile, general and productive syntheses of the fluorescent wye (4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo[1,2-a]purine) in phenylalanine tRNA, its 2-substituted derivatives and 7-aza analogues

Novel syntheses of 4,9-dihydro-4,6-dimethyl-9-oxo-1 H-imidazo[1,2-a]purine (Y base skeleton), its 2-substituted derivatives and 7-aza analogues and their fluorescence characteristics in relation to their structures are described.

Chemical reactivity of alkylguanines. I. Methylation of O6-methylguanine derivatives

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