20535-83-5

Basic information

• Product Name: 6-Methoxyguanine
• Synonyms: O6-METHYLGUANINE;O-METHYLGUANINE;2-amino-6-methoxy-purin;6-methoxy-1h-purin-2-amin;6-methoxy-1h-purine-2-amine;o(sup6)-methylguanine;6-Methoxyguanine;6-methoxy-1h-purin-2-amine
• CAS NO: 20535-83-5
• Molecular Formula: C₆H₇N₅O
• Molecular Weight: 165.16
• EINECS: 1312995-182-4
• Product Categories: Amines;Purine;Chemical Amines;Purines;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Fused Ring Systems;Intermediate in the synthesis of Tropine and respective derivatives
• Mol File: 20535-83-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 598.5 °C at 760 mmHg
• Flash Point: 315.8 °C
• Appearance: Off-white solid
• Density: 1.531 g/cm³
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.814
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly, Heated), Water (Slightly, Heated)
• PKA: 9.74±0.10(Predicted)
• BRN: 645384
• CAS DataBase Reference: 6-Methoxyguanine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxyguanine(20535-83-5)
• EPA Substance Registry System: 6-Methoxyguanine(20535-83-5)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: UO7473000
• Hazardous Substances Data: 20535-83-5(Hazardous Substances Data)

Usage

Uses

Used in Antitumor Applications:
6-Methoxyguanine is used as an antitumor agent, playing a crucial role in the development of cancer therapeutics. Its unique ability to cause DNA transitions makes it a valuable compound for studying the mechanisms of cancer development and progression.
Used in Pharmaceutical Quality Control:
6-Methoxyguanine is used as a pharmaceutical secondary standard for application in quality control. It provides pharmaceutical laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. These secondary standards are qualified as Certified Reference Materials and are suitable for use in several analytical applications, including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Used in Analytical Chemistry:
6-Methoxyguanine is used in various analytical applications, such as the development of new methods for qualitative and quantitative analyses. Its unique chemical properties make it a valuable tool for researchers in the field of analytical chemistry, enabling them to develop more accurate and efficient methods for detecting and quantifying various compounds.

InChI:InChI=1/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2-3H,1H3,(H2,7,8,9,10)

Downstream Products

• 1198-46-5 2-chloro-6-methoxypurine 
• 62962-42-9 N²,3-ethenoguanine 
• 964-21-6 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine 
• 68-94-0 hypoxanthine 
• 7803-88-5 6-O-methylguanosine 
• 67-56-1 methanol 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 1234492-62-6 ((2S,4R)-4-acetoxy-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-methyl-tetrahydrofuran-2-yl)methyl benzoate 
• 2958-98-7 3-methylguanine 
• 879-08-3 9-Ethylguanine 
• 119901-98-3 9-aminoguanine 
• 127770-65-4 3,7-diaminoguanine 
• 177162-17-3 2-amino-7-[2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl]-6-methoxy-7H-purine 

Relevant articles and documents

Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides

A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides: 2,6-diamino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-6-methoxy-9H-purine.