23351-08-8Relevant articles and documents
Pseudo-5-Fold-Symmetrical Ligand Drives Geometric Frustration in Porous Metal-Organic and Hydrogen-Bonded Frameworks
Haase, Frederik,Craig, Gavin A.,Bonneau, Micka?le,Sugimoto, Kunihisa,Furukawa, Shuhei
, p. 13839 - 13845 (2020)
Reticular framework materials thrive on designability, but unexpected reaction outcomes are crucial in exploring new structures and functionalities. By combining "incompatible"building blocks, we employed geometric frustration in reticular materials leadi
Ligand and Cu freeN-arylation of indoles, pyrroles and benzylamines with aryl halides catalyzed by a Pd nanocatalyst
Paul, Abhijit,Chatterjee, Debnath,Banerjee, Srirupa,Yadav, Somnath
supporting information, p. 14447 - 14452 (2020/09/21)
Herein, theN-arylation of aromatic heterocycles like indoles and pyrroles is reported by a Pd nanocatalyst under ligand- and Cu-free conditions. The reaction conditions tolerate several functional groups and work very efficiently for aryl iodides and bromides. Aryl chlorides are also successful as the coupling partners albeit with lower yields. The methodology is also applicable for theN-arylation of aliphatic primary amines as demonstrated by the reactions of benzylamine with several aryl iodides as well as bromides. The recyclable Pd nanocatalyst catalyzes the reaction by a heterogeneous mechanism, which has been demonstrated by several techniques including the three phase test and thein situICP-MS analysis of the reaction mixture.
Design, synthesis, and evaluation of the antimycobacterial activity of 3-mercapto-1,2,4-triazole–pyrrole hybrids
Roman, Gheorghe,Bost?naru, Andra-Cristina,N?stas?, Valentin,Mare?, Mihai
, p. 531 - 546 (2019/10/02)
A series of 3-mercapto-1,2,4-triazole–pyrrole hybrids was designed as antimycobacterial agents by employing 5-(4-(1H-pyrrol-1-yl)phenyl)-4H-1,2,4-triazole-3-thiol as the scaffold onto which several types of moieties were introduced in the triazole ring at N-4 and N-2 and as substituents of the mercapto function. The aforementioned moieties are an allyl or a phenyl moiety at N-4; an aminomethyl group at N-2; or methyl, substituted benzyl, ethoxycarbonylmethyl, or substituted phenacyl at sulfur. Investigation of the compounds in the resulting library as growth inhibitors of Mycobacterium smegmatis showed that their minimum inhibitory concentration was higher than 64 mg/L.