213343-64-7 Usage
Description
(+)-1,2-BIS((2S,5S)-2,5-DIETHYLPHOSPHOLANO)BENZENE(CYCLOOCTADIENE)RHODIUM(L)TETRAFLUOROBORATE, also known as (S,S)-Et-DUPHOS-Rh, is a chiral rhodium complex that serves as a highly efficient and versatile catalyst in various organic synthesis reactions. It is characterized by its dark orange-red solid appearance and plays a crucial role in the asymmetric preparation of biologically active compounds and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
(+)-1,2-BIS((2S,5S)-2,5-DIETHYLPHOSPHOLANO)BENZENE(CYCLOOCTADIENE)RHODIUM(L)TETRAFLUOROBORATE is used as a catalyst for the asymmetric preparation of the B precursor of cryptophycins, which are potent anti-cancer agents. It facilitates the Horner-Wadsworth-Emmons reaction and asymmetric hydrogenation, enabling the synthesis of this key unit.
Used in Peptide Synthesis:
In the field of peptide synthesis, (+)-1,2-BIS((2S,5S)-2,5-DIETHYLPHOSPHOLANO)BENZENE(CYCLOOCTADIENE)RHODIUM(L)TETRAFLUOROBORATE is utilized as a catalyst for the preparation of constrained phenylalanine analogs. These analogs are crucial for the development of novel peptide-based drugs and have potential applications in various therapeutic areas.
Used in Enantioselective Synthesis:
This rhodium complex is employed as a catalyst in the enantioselective preparation of N-benzyloxy-β-amino acid Me esters. It is achieved through the hydrogenation of α-(benzyloxyaminomethyl)acrylate stereoisomers, which are important building blocks in the synthesis of biologically active molecules and pharmaceuticals.
Used in the Synthesis of Fluoro Amino Acids:
(+)-1,2-BIS((2S,5S)-2,5-DIETHYLPHOSPHOLANO)BENZENE(CYCLOOCTADIENE)RHODIUM(L)TETRAFLUOROBORATE is used as a catalyst in the preparation of fluoro amino acids. These synthons are valuable for the development of potent macrocyclic HCV NS3 protease inhibitors, which are crucial in the treatment of Hepatitis C virus infections.
Used in the Preparation of Amino Acids:
This rhodium complex is utilized as a catalyst in the asymmetric hydrogenation of α-(aminomethyl)acrylates, leading to the preparation of β-amino acids. These amino acids are essential components in the synthesis of various pharmaceuticals and biologically active compounds.
Used in Asymmetric Hydrogenation:
(+)-1,2-BIS((2S,5S)-2,5-DIETHYLPHOSPHOLANO)BENZENE(CYCLOOCTADIENE)RHODIUM(L)TETRAFLUOROBORATE is employed as a catalyst in the asymmetric hydrogenation of α-primary and secondary amino ketones. This process is vital for the asymmetric synthesis of various pharmaceuticals, such as (-)-arbutamine and (-)-denopamine, which have potential applications in the treatment of various diseases.
Used in the Preparation of Isotopically Labeled Amino Acids:
In the field of biochemistry and molecular biology, this rhodium complex is used as a catalyst for the stereoselective preparation of triply isotope-labeled Ser, Cys, and Ala. These isotopically labeled amino acids are essential tools for studying protein structure, function, and dynamics.
Reactions
Ligand used in asymmetric hydrogenation of 2-methylenesuccinamic acid.
Ligand used for the Rh-catalyzed asymmetric hydrogenation of α-aminomethylacrylates.
Check Digit Verification of cas no
The CAS Registry Mumber 213343-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,3,3,4 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 213343-64:
(8*2)+(7*1)+(6*3)+(5*3)+(4*4)+(3*3)+(2*6)+(1*4)=97
97 % 10 = 7
So 213343-64-7 is a valid CAS Registry Number.
