181646-38-8

Basic information

• Product Name: Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 181646-38-8
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.26276
• Product Categories: N-BOC
• Mol File: 181646-38-8.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI)(181646-38-8)
• EPA Substance Registry System: Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI)(181646-38-8)

Safety Data

• Hazardous Substances Data: 181646-38-8(Hazardous Substances Data)

Usage

Description

Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI) is an organic compound that serves as an intermediate in the synthesis of various chemical compounds. It is characterized by its carbamic acid structure and ester functional group, which contribute to its reactivity and potential applications in chemical synthesis.

Uses

Used in Pharmaceutical Industry:
Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI) is used as an intermediate in the synthesis of (2E)-5-(tert-Butyloxycarbonylamino)-5-methylhex-2-enoic Acid (B809765). Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI) is further utilized in the preparation of C-terminal sulfonamide analogs of NN703, which are known as growth hormone secretagogues. These growth hormone secretagogues have potential applications in the treatment of growth hormone deficiencies and other related conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, Carbamic acid, (1,1-dimethyl-3-oxopropyl)-, 1,1-dimethylethyl ester (9CI) serves as a key intermediate for the production of various compounds with potential applications in different industries. Its unique structure allows for further modification and functionalization, making it a valuable building block in the synthesis of complex molecules.

Upstream product

• 167216-22-0 tert-butyl (3-hydroxy-1,1-dimethyl-propyl)-carbamate 
• 145486-69-7 methyl 3-<<(tert-butoxy)carbonyl>amino>-3-methylbutanoate 
• 79-37-8 oxalyl dichloride 
• 87413-09-0 Dess-Martin periodane 
• 26939-09-3 2,4,4-trimethyl-5,6-dihydro-1,3(4H)-oxazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 42514-50-1 1-hydroxy-3-methylbut-3-ylamine 
• 129765-95-3 3-[(tert-butoxycarbonyl)amino]-3-methylbutanoic acid 

Downstream Products

• 799296-02-9 {3-[1-(5-benzyl-3-methyl-4-oxo-4,5-dihydro-isothiazolo[5,4-d]pyrimidin-6-yl)-propylamino]-1,1-dimethyl-propyl}-carbamic acid tert-butyl ester 
• 628733-33-5 (+/-)-N-(3-Amino-3-methyl-butyl)-N-[(3-benzyl-7-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-cyclopropyl-methyl]-4-methyl-benzamide 
• 880100-43-6 tert-butyl (4-amino-2-methylbutan-2-yl)carbamate 
• 906648-90-6 tert-butyl {3-[2-(1-ethyl-1-hydroxy-propyl)-phenylamino]-1,1-dimethyl-propyl}-carbamate 
• 918499-50-0 {3-[2-(1-hydroxy-1-propyl-butyl)-phenylamino]-1,1-dimethyl-propyl}-carbamic acid tert-butyl ester 
• 193079-05-9 (E)-5-Amino-5-methyl-hex-2-enoic acid ((R)-1-{[(R)-1-((R)-2-hydroxy-propylcarbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-amide 
• 193079-05-9 (E)-5-Amino-5-methyl-hex-2-enoic acid ((R)-1-{[(R)-1-((S)-2-hydroxy-propylcarbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-amide 
• 213335-92-3 {(E)-4-[((R)-1-{[(R)-1-((R)-2-Hydroxy-propylcarbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1-dimethyl-but-3-enyl}-carbamic acid tert-butyl ester 
• 213335-84-3 {(E)-4-[((R)-1-{[(R)-1-((S)-2-Hydroxy-propylcarbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1-dimethyl-but-3-enyl}-carbamic acid tert-butyl ester 
• 1027896-29-2 {(E)-4-[((R)-2-Biphenyl-4-yl-1-{[(R)-2-(4-fluoro-phenyl)-1-((R)-2-hydroxy-propylcarbamoyl)-ethyl]-methyl-carbamoyl}-ethyl)-methyl-carbamoyl]-1,1-dimethyl-but-3-enyl}-carbamic acid tert-butyl ester 
• 193085-86-8 ((E)-1,1-Dimethyl-4-{methyl-[(R)-1-(methyl-{(R)-2-phenyl-1-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-ethyl}-carbamoyl)-2-naphthalen-1-yl-ethyl]-carbamoyl}-but-3-enyl)-carbamic acid tert-butyl ester 
• 213335-86-5 ((E)-1,1-Dimethyl-4-{methyl-[(R)-1-(methyl-{(R)-2-phenyl-1-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-ethyl}-carbamoyl)-2-naphthalen-2-yl-ethyl]-carbamoyl}-but-3-enyl)-carbamic acid tert-butyl ester 
• 1026241-86-0 {(E)-4-[((R)-2-Biphenyl-4-yl-1-{[(R)-1-((S)-2-hydroxy-propylcarbamoyl)-2-thiophen-2-yl-ethyl]-methyl-carbamoyl}-ethyl)-methyl-carbamoyl]-1,1-dimethyl-but-3-enyl}-carbamic acid tert-butyl ester 
• 213335-88-7 {(E)-4-[((R)-1-{[(R)-1-(Cyclopropylmethyl-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1-dimethyl-but-3-enyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition and formulation containing a derivative of piperlongumine; and use of the derivatives and analogs for treating cancer, reducing inflammation and/or treating an autoimmune or inflammatory disease.

MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

SUBSTITUTED PYRAZOLE AND TRIAZOLE COMPOUNDS AS KSP INHIBITORS

Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof