162713-88-4Relevant articles and documents
Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors
Burke Jr.,Barchi Jr.,George,Wolf,Shoelson,Yan
, p. 1386 - 1396 (1995)
Inhibitors of specific src homology 2 (SH2) domain binding interactions could potentially afford new therapeutic approaches toward a variety of diseases, including several cancers. To date SH2 domain inhibitors have been confined to small phosphotyrosyl (
METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE
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Paragraph 0529; 0630, (2018/06/15)
The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.
Isothiazole derivatives as GPR120 agonists for the treatment of type II diabetes
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, (2015/07/07)
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, G, and Q are defined herein.
GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
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, (2014/09/30)
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.