1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER

Base Information

• Chemical Name: 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER
• CAS No.: 162713-88-4
• Molecular Formula: C14H18 O3
• Molecular Weight: 234.29
• Hs Code.: 2918990090
• Mol file: 162713-88-4.mol

Synonyms:1H-Indene-1-aceticacid, 2,3-dihydro-5-methoxy-, ethyl ester, (?à)-; Ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)acetate

Chemical Property of 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER

Chemical Property:

• Boiling Point: 335.3±35.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.081±0.06 g/cm3(Predicted)
• LogP: 2.67820

Purity/Quality:

≥99% ^*data from raw suppliers

1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER

There total 5 articles about 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 2-[(1E)-5-methoxy-2,3-dihydro-1H-inden-1-ylidene]acetate (21779-34-0) → ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoate (162713-88-4)

Guidance literature:

With hydrogen; palladium; In ethanol;

Reference yield: 97.0%

ethyl (5-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethanoate (73809-30-0) → ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoate (162713-88-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2068.6 Torr;

DOI:10.1021/jm00008a017

Reference yield:

5-methoxy-1-indanone (5111-70-6) + diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) → ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoate (162713-88-4)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 50 ℃; for 1h;

5-methoxy-1-indanone; In tetrahydrofuran; at 0 ℃; for 17h; Reflux;

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 17h;

upstream raw materials:

ethyl (5-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethanoate

ethyl 2-[(1E)-5-methoxy-2,3-dihydro-1H-inden-1-ylidene]acetate

5-methoxy-1-indanone

diethoxyphosphoryl-acetic acid ethyl ester

Downstream raw materials:

(5-{3-[4-(4-tert-butyl-thiazol-2-yl)-2-propyl-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

(5-{3-[2-methoxy-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

(5-{3-[4-(4-ethoxy-5-methyl-thiazol-2-yl)-2-propyl-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

(5-{3-[4-(4-ethoxy-5-ethyl-thiazol-2-yl)-2-methoxy-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

Refernces

• 1、 Wickens, Philip,Zhang, Chengzhi,Ma, Xin,Zhao, Qian,Amatruda, John,Bullock, William,Burns, Michael,Cantin, Louis-David,Chuang, Chih-Yuan,Claus, Thomas,Dai, Miao,Dela Cruz, Fernando,Dickson, David,Ehrgott, Frederick J.,Fan, Dongping,Heald, Sarah,Hentemann, Martin,Iwuagwu, Christiana I.,Johnson, Jeffrey S.,Kumarasinghe, Ellalahewage,Ladner, David,Lavoie, Rico,Liang, Sidney,Livingston, James N.,Lowe, Derek,Magnuson, Steve,Mannelly, Gretchen,Mugge, Ingo,Ogutu, Herbert,Pleasic-Williams, Susan,Schoenleber, Robert W.,Shapiro, Jeff,Shelekhin, Tatiana,Sweet, Laurel,Town, Christopher,Tsutsumi, Manami. "Indanylacetic acids as PPAR-δ activator insulin sensitizers". . p. 4369 - 4373. Retrieved 2007.
• 2、 -. "METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES". Paragraph 0531; 0532. . Retrieved 2018/06/15.
• 3、 -. "ISOTHIAZOLE DERIVATIVES AS GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES". Page/Page column 273-274. . Retrieved 2015/11/02.