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15687-37-3

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15687-37-3 Usage

Description

Naftazone, also known as 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide, is a compound with a 1,2-naphthoquinone substructure. It is recognized for its anti-inflammatory and anti-proliferative properties, making it a potential candidate for pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
Naftazone is used as an anti-inflammatory agent for its ability to reduce inflammation, which can be beneficial in treating various conditions characterized by inflammation.
Naftazone is also used as an anti-proliferative agent due to its capacity to inhibit cell proliferation, which can be useful in managing the growth of abnormal cells, such as in cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 15687-37-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,8 and 7 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 15687-37:
(7*1)+(6*5)+(5*6)+(4*8)+(3*7)+(2*3)+(1*7)=133
133 % 10 = 3
So 15687-37-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H9N3O2/c12-11(16)14-13-9-6-5-7-3-1-2-4-8(7)10(9)15/h1-6H,(H3,12,14,16)

15687-37-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name [(E)-(1-oxonaphthalen-2-ylidene)amino]urea

1.2 Other means of identification

Product number -
Other names Mediaven

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15687-37-3 SDS

15687-37-3Downstream Products

15687-37-3Related news

Acute and chronic haemodynamic effects of naftazone (cas 15687-37-3) in portal hypertensive rats109/06/2019

It has been demonstrated that hyperproduction of nitric oxide (NO) plays a major role in the vasodilatation of cirrhosis; thus, the vasodilatation might be reversed by an inhibition of NO production. Experimental studies in isolated aortic rings showed that naftazone inhibits the effects of NO p...detailed

Fungal metabolite of naftazone (cas 15687-37-3) inhibits nitrite production by activated murine macrophages09/04/2019

The fungus Mucor plumbeus catalyzes the enzymatic cyclization of Naftazone to naphtho-(1,2-e)-(1,2,4)-triazine-(3H)-one. This compound inhibits the induction and the activity of NO synthase by activated murine peritoneal macrophages.detailed

naftazone (cas 15687-37-3) reduces glutamate cerebro spinal fluid levels in rats and glutamate release from mouse cerebellum synaptosomes09/03/2019

It is well known that an excessive release of glutamate in the mammalian brain plays a major role in several neurological diseases. Naftazone (Etioven®) is a currently used vasoprotectant drug that is metabolized in humans by reduction and glucuronidation. In the present study naftazone was foun...detailed

Analytical MethodsSimultaneous determination of clanobutin, dichlorvos, and naftazone (cas 15687-37-3) in pork, beef, chicken, milk, and egg using liquid chromatography-tandem mass spectrometry09/02/2019

A chromatographic method involving a single run was validated for the quantification of clanobutin, dichlorvos, and naftazone in products of animal origin. Pork, beef, chicken, milk, and egg samples were extracted with a solution of 0.1% formic acid in acetonitrile, defatted with n-hexane, centr...detailed

naftazone (cas 15687-37-3) in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial09/01/2019

IntroductionThere is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study.detailed

15687-37-3Relevant articles and documents

Synthesis, characterization, antioxidant, cytotoxic, and DNA cleavage studies of ruthenium(III) complexes containing N-substituted thiosemicarbazone/semicarbazone

Anitha, Panneerselvam,Viswanathamurthi, Periasamy,Misini, Bashkim,Linert, Wolfgang

, p. 1787 - 1795 (2013)

The synthesis, characterization, and biological studies of ruthenium(III) complexes containing ONS/ONO tridentate ligands are reported. Reactions of 1,2-naphthoquinone N-substituted thiosemicarbazone/semicarbazone (HL n ; n = 1-4) with [RuClsu

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