naftazone

Base Information

• Chemical Name: naftazone
• CAS No.: 15687-37-3
• Molecular Formula: C11H9 N3 O2
• Molecular Weight: 215.211
• Hs Code.: 2928000090
• Mol file: 15687-37-3.mol

Synonyms:1,2-Naphthoquinone,2-semicarbazone (8CI); 1,2-Naphthaquinone 2-semicarbazone; Etioven; Haemostop;Haemostop Injection; Karbinon; Karbinone; Mediaven; Naftazon; Naftazone

Chemical Property of naftazone

Chemical Property:

• PSA: 84.55000
• Density: 1.4g/cm³
• LogP: 2.01160

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.

Technology Process of naftazone

There total 3 articles about naftazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

hydrazine carboxamide (4426-72-6,51433-48-8,57-56-7) + 1,2-naphthoquinone (524-42-5) → 1,2-naphthoquinone semicarbazone (15687-37-3)

Guidance literature:

In ethanol; water; for 4h; Reflux;

DOI:10.1007/s00706-013-1097-1

Reference yield:

semicarbazide hydrochloride (563-41-7) + 1,2-naphthoquinone (524-42-5) → 1,2-naphthoquinone semicarbazone (15687-37-3)

Guidance literature:

Reference yield:

→ 1,2-naphthoquinone semicarbazone (15687-37-3)

Guidance literature:

1,2-Naphthoquinone, Semicarbazide*HCl, Na2CO3;

upstream raw materials:

semicarbazide hydrochloride

1,2-naphthoquinone

hydrazine carboxamide

Downstream raw materials:

α-naphthol

Refernces

• 1、 Karpinska, Jolanta,Erxleben, Andrea,Mcardle, Patrick. "Applications of low temperature gradient sublimation in vacuo: Rapid production of high quality crystals. The first solvent-free crystals of ethinyl estradiol". . p. 1122 - 1130. Retrieved 2013.