156441-18-8

Basic information

• Product Name: Pyrrolidine, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-ethenyl-1-(phenylmethyl)-, (2S,4R)-
• CAS NO: 156441-18-8
• Molecular Formula: C19H31NOSi
• Molecular Weight: 317.547
• Mol File: 156441-18-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-ethenyl-1-(phenylmethyl)-, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-ethenyl-1-(phenylmethyl)-, (2S,4R)-(156441-18-8)
• EPA Substance Registry System: Pyrrolidine, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-ethenyl-1-(phenylmethyl)-, (2S,4R)-(156441-18-8)

Safety Data

• Hazardous Substances Data: 156441-18-8(Hazardous Substances Data)

Upstream product

• 154429-40-0 (2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid methyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 154343-02-9 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzyl-2-hydroxy-methyl-pyrrolidin 
• 1031-15-8 methyltriphenylphosphonium chloride 
• 156440-98-1 (2S,4R)-N-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 114676-48-1 (2S,4R)-1-benzyl-4-hydroxyproline methyl ester 

Downstream Products

• 250263-80-0 (2R,4S)-1-allyloxycarbonyl-4-benzoylthio-2-[2-[4-[(E)-2-carbamoylethenyl]imidazol-1-yl]ethyl]pyrrolidine 
• 156442-25-0 (2R,4S)-1-allyloxycarbonyl-2-(2-azidoethyl)-4-(triphenylmethylthio)pyrrolidine 
• 156442-26-1 (2R,4S)-1-allyloxycarbonyl-2-(2-aminoethyl)-4-(triphenylmethylthio)pyrrolidine 
• 156442-44-3 (2R,4S)-1-allyloxycarbonyl-4-benzoylthio-2-[2-(1,2, 4-triazol-1-yl)ethyl]pyrrolidine 
• 156441-19-9 (2R,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-(2-hydroxyethyl)pyrrolidine 

Relevant articles and documents

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapanems. Part III: Novel 2-alkyl substituents containing cationic heteroaromatics linked via a C-N bond

The synthesis and biological activity of a novel series of 2-alkyl-4-pyrrolidinylthio-β-methylcarbapenems containing a variety of cationic heteroaromatic substituents is described. As a result of these studies, we uncovered a relationship between in vitro antibacterial activity and the length of the alkyl spacer part, and discovered FR20950 (1c), containing a two methylene spacer moiety and an imidazolio group, which possesses a balanced spectrum of antibacterial activity, including Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA). Furthermore, FR20950 exhibited excellent urinary recovery, and com- parable stability against renal dehydropeptidase-I (DHP-I) to Biapenem. DHP-I stability could be improved by introduction of a substituent on to the imidazole ring. (C) 1999 Elsevier Science Ltd. All rights reserved.