1450815-87-8

Basic information

• Product Name: C₄₅H₇₇ClFN₅O₁₀P^(1-)*Na⁽¹⁺⁾
• CAS NO: 1450815-87-8
• Molecular Weight: 956.549
• Mol File: 1450815-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₅H₇₇ClFN₅O₁₀P^(1-)*Na⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₅H₇₇ClFN₅O₁₀P^(1-)*Na⁽¹⁺⁾(1450815-87-8)
• EPA Substance Registry System: C₄₅H₇₇ClFN₅O₁₀P^(1-)*Na⁽¹⁺⁾(1450815-87-8)

Safety Data

• Hazardous Substances Data: 1450815-87-8(Hazardous Substances Data)

Upstream product

• 1442651-66-2 2-({[bis(1-methylethyl)amino]-(2-cyanoethoxy)phosphanyl}oxy)propane-1,3-diyldihexadecanoate 
• 123318-82-1 clofarabine 
• 1450815-75-4 2-chloro-9-[2-deoxy-2-fluoro-3-O-(1-hydroxy-1,1,3,3-tetraisopropyldisiloxane-3-yl)-β-d-arabinofuranosyl]-adenine 
• 1450815-72-1 2-chloro-9-[2-deoxy-2-fluoro-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]adenine 

Relevant articles and documents

Synthesis and in vitro cytostatic activity of 1,2- and 1,3- diacylglycerophosphates of clofarabine

The conjugates of anticancer nucleoside clofarabine [2-chloro-9-(2-deoxy-2- fluoro-β-d-arabinofuranosyl)adenine] with 1,2- and 1,3- diacylglycerophosphates have been prepared by the phosphoramidite method using a combination of 1,1,3,3-tetraisopropyldisiloxane-1,3-diyl protecting group for the sugar moiety of the nucleoside and 2-cyanoethyl protection for the phosphate fragment. Some of the synthesized conjugates exhibited cytostatic activity against HL-60, A-549, MCF-7, and HeLa tumor cell lines.