1443623-92-4

Basic information

• Product Name: 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole
• Synonyms: 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole
• CAS NO: 1443623-92-4
• Molecular Weight: 181.185
• Mol File: 1443623-92-4.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole(1443623-92-4)
• EPA Substance Registry System: 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole(1443623-92-4)

Safety Data

• Hazardous Substances Data: 1443623-92-4(Hazardous Substances Data)

Usage

General Description

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole, also known as 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole, is a chemical compound with a molecular formula C10H9F2N. It is a heterocyclic compound with a pyrrole ring structure, containing two fluorine atoms and a phenyl group. 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole has potential pharmaceutical applications and has been studied for its antifungal and antibacterial properties. It may also have potential use in the synthesis of other organic compounds. It is important to handle this chemical with care and follow proper safety precautions when working with it in a laboratory setting.

Upstream product

• 399-94-0 2-bromo-1,4-difluorobenzene 
• 1217630-38-0 (S)-(–)-2-(2,5-difluorophenyl)pyrrolidine 
• 886503-15-7 rac-2-(2,5-difluorophenyl)pyrrolidine 
• 85909-08-6 tert-butyl 2-oxopyrrolidine-1-carboxylate 
• 899819-34-2 (2,5-difluorophenyl)magnesium bromide 
• 540-36-3 para-difluorobenzene 
• 1216260-42-2 4‐chloro‐1‐(2,5-difluorophenyl)butan-1-one 
• 1443538-33-7 tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate 
• 1196551-99-1 tert-butyl 2-(2,5-difluorophenyl)-2-hydroxypyrrole-1-carboxylate 

Downstream Products

• 886503-15-7 rac-2-(2,5-difluorophenyl)pyrrolidine 

Relevant articles and documents

Efficient preparation of (R)-2-(2,5-difluorophenyl)pyrrolidine via a recycle process of resolution

An efficient preparation of (R)-2-(2,5-difluorophenyl)pyrrolidine ((R)-1) from the racemate based on a recycle process of resolution/racemization was described. In the process, the desired (R)-1 was obtained by resolution with D-malic acid in 95% EtOH. Me

Preparation method for intermediate of Larotrectinib

The invention discloses a preparation method for an intermediate of Larotrectinib, belonging to the field of drug synthesis. The preparation method comprises the following steps: with 4-chloro-1-(2,5-difluorophenyl)butane-1-one (I) as a raw material, carrying out a delbin reaction on the 4-chloro-1-(2,5-difluorophenyl)butane-1-one (I) so as to obtain 4-amino-1-(2,5-difluorophenyl)butane-1-one hydrochloride (II), and carrying out intramolecular cyclization under an alkaline condition so as to obtain 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (III). The preparation method provided by the invention is mild in reaction conditions, simple to operate and applicable to industrial production.

Synthesis method of larotrectinib intermediate

The invention discloses a synthesis method of a larotrectinib intermediate, and belongs to the field of drug synthesis. The method uses 4-chloro-1-(2, 5-difluorophenyl)butane-1-one (I) as the raw material to synthesize 5-(2, 5-difluorophenyl)-3, 4-dihydro-2H-pyrrole (III) through ammonolysis and ring closing one-pot method. The invention provides the synthesis method of the larotrectinib intermediate. The method is controllable in reaction process, easy to operate and high in yield.