1431322-84-7

Basic information

• Product Name: (3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one
• Synonyms: (3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one
• CAS NO: 1431322-84-7
• Molecular Weight: 229.279
• Mol File: 1431322-84-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one(1431322-84-7)
• EPA Substance Registry System: (3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one(1431322-84-7)

Safety Data

• Hazardous Substances Data: 1431322-84-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 17342-08-4 (S)-Pyroglutaminol 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 958275-39-3 (3R,7aS)-6-methylene-3-phenyltetrahydropyrrolo[1,2-c]oxazol-5(1H)-one 
• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 1431322-85-8 ((S)-(5-benzyl-5-azaspiro[2.4]heptan-6-yl)methanol) 
• 1262397-14-7 (S)-tert-butyl 6-formyl-5-azaspiro[2.4]heptane-5-carboxylate 
• 1262397-26-1 (S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate 
• 1431663-71-6 (S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone 
• 1431663-65-8 (S)-(2-methyl-5-phenylthiazol-4-yl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone 
• 1445595-57-2 (S)-(6-((isoquinolin-1-ylamino)methyl)-5-azaspiro[2.4]heptan-5-yl)(2-methyl-5-phenylthiazol-4-yl)methanone 
• 1445595-73-2 (S)-(3-(2-fluoro-4-methylphenyl)-6-methylpyridin-2-yl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone 
• 1445595-75-4 (S)-(3-phenylpyridin-2-yl)(6-(((5-(trifluoromethyl)-pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone 
• 1445595-78-7 (S)-4-(6-methyl-2-(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptane-5-carbonyl)pyridin-3-yl)benzonitrile 
• 1445595-82-3 (S)-(3-(3,4-difluorophenyl)-6-methylpyridin-2-yl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone 
• 1445596-11-1 (S)-tert-butyl 6-((((benzyloxy)carbonyl)amino)methyl)-5-azaspiro[2.4]heptane-5-carboxylate 
• 1445596-12-2 (S)-benzyl (5-azaspiro[2.4]heptan-6-ylmethyl)carbamate 
• 1445596-13-3 (S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate 
• 1129634-44-1 (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid 

Relevant articles and documents

Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists

Starting from a orexin 1 receptor selective antagonist 4,4-disubstituted piperidine series a novel potent 5-azaspiro[2.4]heptane dual orexin 1 and orexin 2 receptor antagonist class has been discovered. SAR and Pharmacokinetic optimization of this series

PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES

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