17342-08-4

Basic information

• Product Name: L-Pyroglutaminol
• Synonyms: 2-Pyrrolidinone, 5-(hydroxyMethyl)-, (5S)-;L-Pyr-OL;(S)-5-(Hydroxymethyl)-2-pyrrolidinone,99%e.e.;(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;TIMTEC-BB SBB004302;PYROGLUTAMINOL;PGLU-OL
• CAS NO: 17342-08-4
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13
• EINECS: -0
• Product Categories: pharmacetical;Pyrrolidine series;Heterocyclic Compounds;Amides (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Heterocycles;Miscellaneous Reagents
• Mol File: 17342-08-4.mol
• Article Data: 69

Chemical Properties

• Melting Point: 79-80 °C(lit.)
• Boiling Point: 147-149°C 0,06mm
• Flash Point: 147-149°C/0.06m
• Appearance: White to light yellow/Crystals or Crystalline Powder
• Density: 1.1808 (rough estimate)
• Refractive Index: 31 ° (C=5, EtOH)
• Storage Temp.: Store at 0-5°C
• Solubility: DMSO, Ethanol, Methanol
• PKA: 14.35±0.10(Predicted)
• Water Solubility: Soluble in water.
• BRN: 4657914
• CAS DataBase Reference: L-Pyroglutaminol(CAS DataBase Reference)
• NIST Chemistry Reference: L-Pyroglutaminol(17342-08-4)
• EPA Substance Registry System: L-Pyroglutaminol(17342-08-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 17342-08-4(Hazardous Substances Data)

Usage

Description

L-Pyroglutaminol, also known as (S)-Pyroglutaminol, is a compound that is valuable in the field of organic synthesis. It is characterized by its white to light yellow crystalline appearance and possesses unique chemical properties that make it a versatile component in various chemical reactions and processes.

Uses

Used in Organic Synthesis:
L-Pyroglutaminol is used as a key compound in organic synthesis for its ability to participate in a wide range of chemical reactions. Its unique chemical properties allow it to be a versatile building block in the creation of more complex molecules and structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, L-Pyroglutaminol is used as an intermediate in the synthesis of various drugs and medications. Its role in creating complex molecular structures makes it an essential component in the development of new and innovative pharmaceutical products.
Used in Chemical Research:
L-Pyroglutaminol is also utilized in chemical research as a tool to study and understand the behavior of different chemical reactions. Its unique properties and reactivity make it an ideal candidate for exploring new reaction pathways and mechanisms.

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 142-47-2 glutamic acid sodium salt 
• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 56-86-0 L-glutamic acid 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 74936-93-9 (S)-5-oxopyrrolidine-2-carbonyl chloride 
• 4931-66-2 methyl (S)-pyroglutamate 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 4931-66-2 (S)-5-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester 

Downstream Products

• 222307-13-3 (S)-(+)-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one 
• 142890-28-6 diethyl [(S)-azabicyclo[3.1.0]hex-2-ylidene]malonate 
• 153649-62-8 2-(2-hydroxymethyl-pyrrolidin-5-ylidene)-malonic acid diethyl ester 
• 142890-23-1 2-(2-bromomethyl-pyrrolidin-5-ylidene)-malonic acid diethyl ester 
• 142890-25-3 2-((S)-5-Iodomethyl-pyrrolidin-2-ylidene)-malonic acid diethyl ester 
• 142890-29-7 (S)-2-(1-Aza-bicyclo[3.1.0]hex-2-ylidene)-malonic acid dibenzyl ester 
• 153649-64-0 2-((S)-5-Hydroxymethyl-pyrrolidin-2-ylidene)-malonic acid dibenzyl ester 
• 142890-24-2 2-((S)-5-Bromomethyl-pyrrolidin-2-ylidene)-malonic acid dibenzyl ester 
• 142890-26-4 2-((S)-5-Iodomethyl-pyrrolidin-2-ylidene)-malonic acid dibenzyl ester 
• 142890-19-5 2-[(S)-5-(Toluene-4-sulfonyloxymethyl)-pyrrolidin-2-ylidene]-malonic acid diethyl ester 
• 142890-15-1 (S)-diethyl 2-(2-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-5-ylidene)malonate 
• 142890-20-8 2-[(S)-5-(Toluene-4-sulfonyloxymethyl)-pyrrolidin-2-ylidene]-malonic acid dibenzyl ester 
• 142890-16-2 2-[(S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-ylidene]-malonic acid dibenzyl ester 
• 170148-26-2 (S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-methoxy-3,4-dihydro-2H-pyrrole 

Relevant articles and documents

N-Heterocyclic carbene triazolium salts containing brominated aromatic motifs: Features and synthetic protocol

In this work, we provide a brief overview of the role of N-aryl substituents on triazolium N-heterocyclic carbene (NHC) catalysis. This synopsis provides context for the disclosed synthetic protocol for new chiral N-heterocyclic carbene (NHC) triazolium salts with brominated aromatic motifs. Incorporating brominated aryl rings into NHC structures is challenging, probably due to the substantial steric and electronic influence these substituents exert throughout the synthetic protocol. However, these exact characteristics make it an interesting N-aryl substituent, because the electronic and steric diversity it offers could find broad use in organometallic- A nd organo-catalysis. Following the synthetic reaction by NMR guided the extensive modification of a known protocol to enable the preparation of these challenging NHC pre-catalysts.

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

5-HT7 Receptor Antagonists with an Unprecedented Selectivity Profile

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