1415800-43-9

Basic information

• Product Name: UNC-1215
• Synonyms: UNC 1215;UNC1215;UNC-1215;(2-(phenylaMino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)Methanone);1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone];UNC1215 1,1'-[2-(PhenylaMino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]Methanone];Methanone, 1,1'-[2-(phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]-;1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone] UNC 1215
• CAS NO: 1415800-43-9
• Molecular Formula: C₃₂H₄₃N₅O₂
• Molecular Weight: 529.71612
• Product Categories: Inhibitors
• Mol File: 1415800-43-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 712.1±60.0 °C(Predicted)
• Appearance: white to beige/
• Density: 1.224±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble5mg/mL, clear
• PKA: 9.90±0.20(Predicted)
• CAS DataBase Reference: UNC-1215(CAS DataBase Reference)
• NIST Chemistry Reference: UNC-1215(1415800-43-9)
• EPA Substance Registry System: UNC-1215(1415800-43-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1415800-43-9(Hazardous Substances Data)

Usage

Description

UNC-1215 is a potent and selective antagonist of L3MBTL3, a protein that plays a role in various cellular processes. It has the ability to bind the MBT domains of L3MBTL3 with a dissociation constant (Kd) of 120 nM, competitively displacing peptides containing monoor dimethyl-lysine.

Uses

Used in Pharmaceutical Industry:
UNC-1215 is used as a research tool for studying the role of L3MBTL3 in cellular processes and its potential as a therapeutic target. Its high selectivity and potency make it a valuable compound for investigating the underlying mechanisms of diseases and developing targeted treatments.
Used in Drug Development:
As a potent and selective antagonist of L3MBTL3, UNC-1215 can be used in the development of new drugs that target this protein. This could potentially lead to the creation of novel therapeutics for various diseases and conditions where L3MBTL3 plays a significant role.
Used in Epigenetic Research:
L3MBTL3 is an enzyme that can read the chemical modifications on histones, which are proteins that help package and organize DNA. UNC-1215, by inhibiting L3MBTL3, can be used to study the epigenetic regulation of gene expression and its impact on cellular processes and disease development.
Used in Cancer Research:
Since L3MBTL3 has been implicated in cancer, UNC-1215 could be used as a starting point for developing targeted therapies against certain types of cancer. Its ability to inhibit L3MBTL3 may help in understanding the role of this protein in cancer progression and identifying potential therapeutic strategies.

Upstream product

• 566155-75-7 2-(phenylamino)terephthalic acid 
• 5004-07-9 4-(1-pyrrolidinyl)piperidine 
• 5372-81-6 dimethyl aminoterephthalate 
• 5292-45-5 dimethyl 2-nitroterephthalate 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 

Relevant articles and documents

Compound a preparation UNC1215 method

The invention discloses a method for preparing a compound UNC1215, belonging to the technical field of pharmaceutical chemistry synthesis. The method sequentially comprises the following steps: nitration, nitro reduction reaction, Buchwald reaction, esterolysis reaction, condensation reaction and the like. The overall reaction yield can reach 67%, which is higher than the yield (60%) in the document. The method changes the synthesis route, avoids the pipe sealing reaction, sequentially performs the nitration, reduction reaction, Buchwald reaction, hydrolysis reaction and condensation reaction, and is simple to operate.