UNC-1215

Base Information

• Chemical Name: UNC-1215
• CAS No.: 1415800-43-9
• Molecular Formula: C32H43N5O2
• Molecular Weight: 529.726
• Hs Code.: 2933998090
• Mol file: 1415800-43-9.mol

Synonyms:CS-714;UNC1215;UNC 1215;UNC-1215;UNC 1215, >=98%;UNC 1215; UNC1215;UNC-1215 USP/EP/BP;N-Phenyl-2,5-bis({[4-(pyrrolidin-1-yl)piperidin-1-yl]carbonyl})aniline;(2-(phenylaMino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)Methanone);1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone]

Chemical Property of UNC-1215

Chemical Property:

• Boiling Point: 712.1±60.0 °C(Predicted)
• PKA: 9.90±0.20(Predicted)
• PSA: 59.13000
• Density: 1.224±0.06 g/cm3(Predicted)
• LogP: 4.65560
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble5mg/mL, clear

Purity/Quality:

98% min ^*data from raw suppliers

UNC1215 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: UNC 1215 is ; a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 binds the MBT domains of L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyl-lysine containi ng peptides UNC 1215 is ; a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 binds the MBT domains of L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyl-lysine containing peptides

Technology Process of UNC-1215

There total 4 articles about UNC-1215 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

2-(phenylamino)terephthalic acid (566155-75-7) + 4-(1-pyrrolidinyl)piperidine (5004-07-9) → (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone) (1415800-43-9)

Guidance literature:

2-(phenylamino)terephthalic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 1h; Inert atmosphere; Cooling;

4-(1-pyrrolidinyl)piperidine; In N,N-dimethyl-formamide; Reagent/catalyst; Inert atmosphere;

Reference yield:

1,4-benzenedicarboxylic acid dimethyl ester (120-61-6) → (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone) (1415800-43-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 1 h / 20 °C / Cooling

2.1: ammonium chloride; iron / ethanol; water / 0.5 h / Reflux

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / toluene / 6 h / Inert atmosphere; Reflux

4.1: lithium hydroxide monohydrate / ethanol / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / Inert atmosphere; Cooling

5.2: Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; XPhos; In ethanol; water; N,N-dimethyl-formamide; toluene; 3.1: |Buchwald-Hartwig Coupling;

Reference yield:

dimethyl 2-nitroterephthalate (5292-45-5) → (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone) (1415800-43-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium chloride; iron / ethanol; water / 0.5 h / Reflux

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / toluene / 6 h / Inert atmosphere; Reflux

3.1: lithium hydroxide monohydrate / ethanol / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / Inert atmosphere; Cooling

4.2: Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; XPhos; In ethanol; water; N,N-dimethyl-formamide; toluene; 2.1: |Buchwald-Hartwig Coupling;

upstream raw materials:

1,4-benzenedicarboxylic acid dimethyl ester

dimethyl 2-nitroterephthalate

dimethyl aminoterephthalate

2-(phenylamino)terephthalic acid

Refernces