139693-52-0

Basic information

• Product Name: 6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate
• Synonyms: 6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate;Moxifloxacin Impurity I;Moxifloxacin Boron Complex Impurity;6-cyclopropyl-8,9-difluoro-7-methoxy- 4-oxo-4,6-dihydro-2H-1l3,2l4- [1,3,2]dioxaborinino[5,6-c]quinoline- 2,2-diyl diacetate
• CAS NO: 139693-52-0
• Molecular Formula: C₁₈H₁₆BF₂NO₈
• Molecular Weight: 425.3369864
• Mol File: 139693-52-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate(139693-52-0)
• EPA Substance Registry System: 6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate(139693-52-0)

Safety Data

• Hazardous Substances Data: 139693-52-0(Hazardous Substances Data)

Usage

Description

6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate is a complex organic compound with a unique chemical structure. It is characterized by its cyclopropyl, difluoro, methoxy, and oxo groups, which contribute to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate is used as a potential pharmaceutical compound for its in vitro antibacterial activity. The compound is studied for its ability to inhibit bacterial growth, making it a candidate for the development of new antibiotics to combat drug-resistant bacteria.
Used in Chemical Research:
In the field of chemical research, 6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-1l3-[1,3]dioxino[5,6-c]quinoline-2,2-diyl diacetate can be used as a starting material or intermediate in the synthesis of other complex organic molecules. Its unique structure may provide insights into the development of new chemical reactions and methodologies.
Used in Material Science:
The compound's specific properties, such as its fluorinated and cyclopropyl groups, may make it suitable for use in the development of new materials with unique characteristics. It could potentially be utilized in the creation of advanced materials for various applications, including electronics, coatings, or adhesives.

Upstream product

• 11113-50-1 boric acid 
• 108-24-7 acetic anhydride 
• 112811-72-0 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 112811-71-9 ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 4887-24-5 triacetoxyborane 
• 1103242-32-5 boron trioxide 

Downstream Products

• 186826-86-8 moxifloxacin hydrochloride 
• 1446946-23-1 7-[3-amino-4-(4'-bromo-2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-25-3 7-[3-amino-4-(2',5'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-26-4 7-[3-amino-4-(3',5'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-27-5 7-[3-amino-4-(2',3'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-28-6 7-[3-amino-4-(3',4'-dimethoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-30-0 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-31-1 7-[3-amino-4-(3'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-32-2 7-[3-amino-4-(4'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-33-3 7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-34-4 7-[3-amino-4-(4'-chlorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1446946-35-5 7-(3-amino-4-benzyloxyiminopiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1394029-14-1 moxifloxacin hydrochloride 
• 172426-88-9 7-amino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 

Relevant articles and documents

Synthesis method of moxifloxacin hydrochloride oxide impurity

The invention relates to a synthesis method of a moxifloxacin hydrochloride oxide impurity as shown in a formula I-1. The method comprises the following steps: step 1) reacting a compound I-5 with a compound I-4 to obtain a compound I-6; and 2) removing a protecting group from the compound I-6 prepared in the step 1) under an acidic condition to obtain a compound I-1, namely the moxifloxacin hydrochloride oxide impurity.

Preparation method of moxifloxacin hydrochloride (by machine translation)

The invention relates to a preparation method of moxifloxacin hydrochloride. , 1 - Cyclopropyl -7 - (S, S-2, diazabicyclo [4.3.0] nonane -8 - yl) -6 - fluoro -8 - methoxy -4 - oxo -1, 4 - dihydro -3 - quinoline carboxylic acid hydrochloride is prepared. The condensation reaction solvent acetonitrile is recovered after a certain technical means is recovered to form a condensation product borane chelating moxifloxacin, and the condensation reaction solvent acetonitrile can be reused for the condensation reaction step after the condensation reaction solvent acetonitrile is recovered by a certain technical means. The condensate is hydrolyzed with sodium hydroxide solution in acetone, and then pH is adjusted to acid by hydrochloric acid to form a moxifloxacin hydrochloride crude product, and the crude product is refined after refining in a mixture of ethanol and water to obtain refined moxifloxacin hydrochloride. To the method, the condensation reaction temperature is reduced, the product purity is improved, the emission of three wastes is reduced, the production cost is reduced, and the method is suitable for industrial production. (by machine translation)

Moxifloxacin hydrochloride new preparation method

The invention provides a method for preparing a moxifloxacin intermediate and moxifloxacin hydrochloride, which comprises the following steps: carrying out condensation reaction on main ring chelate disclosed as Formula (I) and (S,S)-2,8-diazabicyclo-[4.3.0]nonane in the presence of an acid acceptor in a solvent, acidifying for salification, crystallizing, filtering, washing and drying to obtain the moxifloxacin hydrochloride. The method is characterized in that the solvent in the condensation reaction is alcohol. The condensation reaction is carried out in the alcohol solvent at the controlled temperature of 30-80 DEG C (preferably lower temperature), so the method has the advantage of mild reaction conditions, greatly reduces the generation of impurities, saves the energy; the alcohol solvent can be directly acidified after sufficient reaction, thereby saving the complex step of removing acetonitrile by evaporation and greatly simplifying the steps; and the method is suitable for industrial production.