112811-71-9Relevant articles and documents
COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS
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Page/Page column 59; 61, (2021/09/11)
The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.
Preparation method of 1-cyclopropyl-6,7-difluoro-8-methoxyfluoroquinolone-3-carboxylate
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, (2020/06/17)
The invention discloses a preparation method of 1-cyclopropyl-6,7-difluoro-8-methoxyfluoroquinolone-3-carboxylate, wherein the 1-cyclopropyl-6,7-difluoro-8-methoxyfluoroquinolone-3-carboxylate is prepared by taking 2-(2,3,4,5-tetrafluorophenyl)formyl-3-(N,N-dimethylamino)acrylate prepared from cheap and easily available 2,3,4,5-tetrafluorobenzoyl chloride as a raw material through substitution, secondary ring closing, hydrolysis and secondary substitution reaction. The preparation method has the advantages of environmental protection, no pollution, easily available raw materials, wide raw material source, low cost and simple method, is suitable for industrial production, and solves the problems that in the prior art, the preparation cost is high, and industrial production is difficult.
Novel fluoroquinolones and use thereof to treat bacterial infections
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, (2016/01/12)
The present invention relates to novel fluoroquinolones possessing a piperazine moiety substituted by a long alkyl chain, pharmaceutical compositions or medicament containing them and use thereof to treat bacterial infection.