13909-56-3

Basic information

• Product Name: 2-Propen-1-one, 3-(4-methylphenyl)-1-(4-nitrophenyl)-
• CAS NO: 13909-56-3
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.284
• Mol File: 13909-56-3.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(4-methylphenyl)-1-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(4-methylphenyl)-1-(4-nitrophenyl)-(13909-56-3)
• EPA Substance Registry System: 2-Propen-1-one, 3-(4-methylphenyl)-1-(4-nitrophenyl)-(13909-56-3)

Safety Data

• Hazardous Substances Data: 13909-56-3(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 100-19-6 (4-nitrophenyl)ethanone 
• 555-16-8 4-nitrobenzaldehdye 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 622-47-9 4-tolylacetic acid 
• 62-23-7 4-nitro-benzoic acid 
• 1450853-35-6 2-(4-nitrophenyl)-4-p-tolylpyrano[3,2-c]chromen-5(4H)-one 
• 1390627-15-2 3-(4-nitrophenyl)-5-p-tolyl-4,5-dihydroindeno[1,2-c][1,2]diazepin-6(1H)-one 
• 1390626-97-7 2-(3-(4-nitrophenyl)-3-oxo-1-p-tolylpropyl)-2H-indene-1,3-dione 
• 1295506-60-3 (3-(4-chlorophenyl)-4-p-tolylisoxazol-5-yl)(4-nitrophenyl)methanone 
• 25870-86-4 1-(4-isothiocyanatophenyl)-3-(4-methylphenyl)-2-propen-1-one 

Relevant articles and documents

Nano-TiO2: an eco-friendly and re-usable catalyst for the one-pot synthesis of β-acetamido ketones

Nano-TiO2 as an efficient, eco-friendly and reusable catalyst was applied for the one-pot synthesis of β-acetamido ketones. In this improved procedure, an aryl aldehyde, an aryl ketone, acetyl chloride and acetonitrile were condensed in the pre

Chalcone-Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering

Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone morphogenetic protein 4 (BMP4) is key for early cardiac mesoderm induction in hPSC and subsequent cardiomyocyte derivation. Small-molecular BMP4 mimetics may help to standardize cardiomyocyte derivation from hPSCs. Based on observations that chalcones can stimulate BMP4 signaling pathways, we hypothesized their utility in cardiac mesoderm induction. To test this, we set up a two-tiered screening strategy, (1) for directed differentiation of hPSCs with commercially available chalcones (4’-hydroxychalcone [4’HC] and Isoliquiritigen) and 24 newly synthesized chalcone derivatives, and (2) a functional screen to assess the propensity of the obtained cardiomyocytes to self-organize into contractile engineered human myocardium (EHM). We identified 4’HC, 4-fluoro-4’-methoxychalcone, and 4-fluoro-4’-hydroxychalcone as similarly effective in cardiac mesoderm induction, but only 4’HC as an effective replacement for BMP4 in the derivation of contractile EHM-forming cardiomyocytes.

Design, Synthesis, and Antimicrobial Evaluation of Novel [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazepine Derivatives

Abstract: The title compounds,3,3′,3″,3′′′-[methylenebis(oxybenzene-5,1,3-triyl)]tetrakis(6,8-diaryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines), were synthesized startingfrom dimethyl 4-hydroxyisophthalate which was reacted with dibromomethane toobtain tetramethyl 5,5′-[methylenebis(oxy)]di(benzene-1,3-dicarboxylate). Thelatter was treated with excess hydrazine hydrate, and the resultingtetrahydrazide was converted to tetrakis-1,2,4-triazolyl derivative viacyclization with ethanolic potassium hydroxide, carbon disulfide, and hydrazinehydrate. In the final stage, cyclocondensation with substituted chalconesafforded the target products. The structure of the newly synthesized compoundswas confirmed by elemental analyses and FT-IR and NMR spectra, and theirantimicrobial activities against some bacterial and fungal strains wereestimated by the disc diffusion method.