138337-22-1

Basic information

• Product Name: cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one
• CAS NO: 138337-22-1
• Molecular Weight: 388.894
• Mol File: 138337-22-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one(138337-22-1)
• EPA Substance Registry System: cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one(138337-22-1)

Safety Data

• Hazardous Substances Data: 138337-22-1(Hazardous Substances Data)

Upstream product

• 107967-01-1 1,3,4,5-tetrahydro-7-chloro-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 5367-28-2 5-chloro-2-nitrotoluene 
• 138334-95-9 cis-1,3,4,5-tetrahydro-7-chloro-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 107966-98-3 [2-(5-chloro-2-nitrophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester 
• 107966-99-4 [2-(2-amino-5-chlorophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester 
• 107967-00-0 1,3,4,5-tetrahydro-7-chloro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 
• 138337-22-1 cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one 
• 107967-01-1 7-Chloro-1,3,4,5-tetrahydro-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 

Downstream Products

• 138334-33-5 cis-1,3,4,5-tetrahydro-7-chloro-3-acetoxy-1-<2-(dimethylamino)ethyl>-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 138383-37-6 (3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one 
• 138337-22-1 (3S,4R-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one 

Relevant articles and documents

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).