1299491-15-8

Basic information

• Product Name: (R)-N-[2-hydroxy-2-{4-(trifluoromethyl)phenyl}ethyl]benzamide
• CAS NO: 1299491-15-8
• Molecular Weight: 309.288
• Mol File: 1299491-15-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-N-[2-hydroxy-2-{4-(trifluoromethyl)phenyl}ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-[2-hydroxy-2-{4-(trifluoromethyl)phenyl}ethyl]benzamide(1299491-15-8)
• EPA Substance Registry System: (R)-N-[2-hydroxy-2-{4-(trifluoromethyl)phenyl}ethyl]benzamide(1299491-15-8)

Safety Data

• Hazardous Substances Data: 1299491-15-8(Hazardous Substances Data)

Upstream product

• 81561-66-2 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine 
• 98-88-4 benzoyl chloride 
• 778581-67-2 2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3-oxazole 
• 339-58-2 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 1299491-08-9 (R)-2-phenyl-5-[4-(trifluoromethyl)phenyl]oxazoline 
• 1299491-27-2 2-(N-benzoylamino)-1-[4-(trifluoromethyl)phenyl]-1-ethanone 
• 874813-04-4 2-azido-1-[4-(trifluoromethyl)phenyl]-1-ethanone 

Downstream Products

• 1299491-31-8 C₂₅H₂₂F₃NO₄ 
• 1299491-35-2 C₂₅H₂₂F₃NO₄ 

Relevant articles and documents

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein

Chiral 1,2-amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes to unprotected, enantioenriched amino alcohols remains a challenge. Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. The reaction is proposed to proceed via a reactive iron-nitrogen species generated in the enzyme active site, enabling tuning of the catalyst's activity and selectivity by protein engineering.