81561-66-2

Basic information

• Product Name: 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine
• CAS NO: 81561-66-2
• Molecular Weight: 205.18
• Mol File: 81561-66-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine(81561-66-2)
• EPA Substance Registry System: 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine(81561-66-2)

Safety Data

• Hazardous Substances Data: 81561-66-2(Hazardous Substances Data)

Upstream product

• 32687-39-1 2-bromo-1-(4-(trifluoromethyl)phenyl)ethanol 
• 339-58-2 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 771582-55-9 2-amino-1-[4-(trifluoromethyl)phenyl]ethanone 
• 906482-51-7 2-(4-Trifluoromethyl-phenyl)-2-trimethylsilanyloxy-propionitrile 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 73183-23-0 2-(4-(trifluoromethyl)phenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 168013-75-0 (+/-)-2-hydroxy-2-(4-trifluoromethylphenyl)acetonitrile 

Downstream Products

• 1383925-61-8 (+/-)-2-(pyrid-2-yl)-5-[4-(trifluoromethyl)phenyl]-1,3-oxazoline 
• 16187-73-8 2-chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}acetamide 
• 62243-72-5 2-[4-(trifluoromethyl)phenyl]morpholine 
• 7125-73-7 6-[4-(trifluoromethyl)phenyl]morpholin-3-one 
• 864539-94-6 tert-butyl (2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)carbamate 

Relevant articles and documents

RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE

Provided herein are compounds as RORγ antagonist having Formula (I). The compounds or pharmaceutical composition thereof can be used for regulating Retinoid-related orphan receptor gamma t (RORγt). Also provided herein are methods of preparation of the compounds and composition thereof, and uses thereof in treating or preventing RORγt mediated inflammation or autoimmune diseases in mammals, particularly humans.

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A MORPHOLINE MOIETY

The disclosure provides compounds of formula (I) or pharmaceutically acceptable salts thereof: The disclosure also provides processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them, and their use

Direct catalytic synthesis of unprotected 2-amino-1-phenylethanols from alkenes by using iron(II) phthalocyanine

Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products. Herein, we report that an exceptionally simple and inexpensive FeII complex efficiently catalyzes the direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity. This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.