1227853-06-6

Basic information

• Product Name: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine
• Synonyms: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine
• CAS NO: 1227853-06-6
• Molecular Weight: 579.051
• Mol File: 1227853-06-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine(1227853-06-6)
• EPA Substance Registry System: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine(1227853-06-6)

Safety Data

• Hazardous Substances Data: 1227853-06-6(Hazardous Substances Data)

Upstream product

• 104458-24-4 2-(methylsulfonyl)ethylamine hydrochloride 
• 231278-84-5 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde 
• 851684-46-3 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine hydrochloride 
• 1440511-83-0 2-chloro-4-(6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-ylamino)phenol 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 1440511-82-9 5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-carbaldehyde tosylate 
• 1440511-81-8 5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-carbaldehyde 
• 908332-08-1 2-chloro-4-(6-iodoquinazolin-4-ylamino)phenol 
• 3964-52-1 2-chloro 4-aminophenol 
• 98556-31-1 4-chloro-6-iodoquinazoline 
• 1227853-05-5 N⁽¹⁾-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine 
• 202197-26-0 3-chloro-4-(3-fluorobenzyloxy)aniline 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 903597-10-4 N’-(2-cyano-4-iodophenyl)-N,N-dimethyl formamidine 

Downstream Products

• 231277-92-2 lapatanib 
• 388082-78-8 lapatinib ditosylate 

Relevant articles and documents

An environment friendly process for the preparation of Lapatinib Ditosylate of Formula 1(b)

The present invention relates to a process for the preparation of Lapatinib Ditosylate of formula 1(b). More particularly, the present invention relates to environment friendly process that involves green chemistry in preparation of Lapatinib Ditosylate of formula 1(b). The said process is economically and commercially viable as initial 2 stages of processes use water as solvent avoiding hazardous reagent or solvent during the preparation of Lapatinib Ditosylate of formula 1(b).

NOVEL PROCESS FOR THE PREPARATION OF LAPATINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to an improved and novel process for the preparation of high purity crystalline base of Lapatinib of formula-(1) having chemical name N-{3-chloro-4-[(3-fluorobenzyloxy]phenyl}-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl]-2-furyl]-4-quin-azolinamine and its pharmaceutically acceptable salts. The present invention further relates to intermediates according to formula (8) and formula (9) used in this process

A NOVEL PROCESS FOR THE PREPARATION OF LAPATINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to an improved and novel process for the preparation of high purity crystalline base of Lapatinib of formula-(l) having chemical name N-{3-chloro-4-[(3- fluorobenzyloxy]phenyl}-6-[5-({[2-(methanesuIfonyl) ethyl]amino}methyl]-2-furyl]-4-quin - azolinamine and its pharmaceutically acceptable salts. The present invention further relates to intermediates according to formula (8) and formula (9) used in this process