27329-70-0 Usage
Description
2-Formylfuran-5-boronic acid is an organic compound with the chemical formula C5H5BO3. It is a beige to brown powder and is known for its versatile reactivity in various chemical reactions, particularly in the field of organic synthesis.
Uses
Used in Chemical Synthesis:
2-Formylfuran-5-boronic acid is used as a bifunctional reagent for the synthesis of π-extended heteroarylfuran systems. Its unique structure allows for the formation of complex molecular structures with potential applications in various industries.
Used in Suzuki Reaction:
In the field of organic chemistry, 2-Formylfuran-5-boronic acid is used as a reactant in Suzuki coupling, a widely employed method for the formation of carbon-carbon bonds. This reaction is particularly useful for the synthesis of stable dye-sensitized solar cells, contributing to the development of renewable energy technologies.
Used in Pharmaceutical Industry:
2-Formylfuran-5-boronic acid is used as a reactant in the synthesis of biologically active molecules. It plays a crucial role in the development of various pharmaceutical compounds, such as:
HIF-1 inhibitors: These molecules are involved in the regulation of cellular responses to hypoxia and have potential applications in the treatment of cancer and other diseases.
Disalicylic acid-furanyl derivatives: These compounds are designed to inhibit ephrin binding, which can be useful in the development of drugs targeting various signaling pathways.
HIV-1 integrase inhibitors: These molecules are essential in the development of antiretroviral drugs, as they help prevent the integration of the HIV virus into the host genome.
Epidermal growth factor receptor inhibitors: These compounds are used in the treatment of various cancers by targeting the epidermal growth factor receptor, a key player in cell proliferation and survival.
Check Digit Verification of cas no
The CAS Registry Mumber 27329-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,3,2 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 27329-70:
(7*2)+(6*7)+(5*3)+(4*2)+(3*9)+(2*7)+(1*0)=120
120 % 10 = 0
So 27329-70-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H5BO4/c7-3-4-1-2-5(10-4)6(8)9/h1-3,8-9H
27329-70-0Relevant articles and documents
Copper-Catalyzed Monoorganylation of Trialkyl Borates with Functionalized Organozinc Pivalates
Fu, Ying,Gou, Bei-Lei,Shi, Chun-Zhao,Du, Zhengyin,Shen, Tong
, p. 4253 - 4257 (2018/09/18)
Organozinc pivalates, a recently developed air- and moisture-stable organozinc species, were found for the first time as excellent organometallic species in the monoorganylation of trialkyl borates whereby boronic acids were prepared in high yields. The significant advantage of organozinc pivalates over another previously employed organometallic reagents, e. g., organolithium reagents, Grignard reagents and organozinc halides, is that the generation of multiorganylation byproducts such as borinic acids and trialkylboranes were completely suppressed. Additionally, the in situ generated boronates could be directly arranged into Suzuki-Miyaura type cross-coupling reactions to produce biaryls in high yields.
METHODS FOR DETECTING AND REDUCING IMPURITIES OF LAPATINIB AND SALTS THEREOF
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, (2012/12/13)
Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
Method of producing 5-formyl-2-furylboronic acid
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Page 3, 4, (2008/06/13)
The present invention refers to an improved method of producing 5-formyl-2-furylboronic acid. The method is carried out in a three-step process comprising the steps of:a) addition of a base to a composition comprising a boric acid ester and 2-furaldehyde whereby the formyl functionality of the 2-furaldehyde is protected with a protective group, andb) acidic work-up of the reaction mixture of step a), andc) isolation of 5-formyl-2-furylboronic acid.