106896-49-5Relevant articles and documents
Synthesis of phenazine-2,8-dicarboxylates
Bhadbhade, Mohan M.,Constable, Grace E. O.,Hunter, Luke,Jung, Jane,Read, Roger W.,Wakelin, Laurence P. G.
supporting information, (2022/01/12)
Phenazine is a tricyclic heteroarene that forms the core of diverse functional molecules including DNA intercalators. However, 2,8-disubstituted phenazines are rare, and this potentially limits the medicinal development of this class of heterocycles. Here we describe the synthesis of two new members of this compound class (i.e. dimethyl phenazine-2,8-dicarboxylate and the corresponding diacid), following a synthetic route that involved inter- and intramolecular Buchwald-Hartwig N-arylations. We also detail a simple NMR-based method for proving the 2,8-disubstitution pattern, in order to counterbalance suspected structural misassignments elsewhere in the peer-reviewed and patent literature.
Synthesis and biological evaluation of an antibacterial azaborine retinoid isostere
Haney, Brittney A.,Schrank, Cassandra L.,Wuest, William M.
, (2020/12/07)
Our continued synthetic interest in this class of retinoids, CD437 and its analogs, against methicillin-resistant Staphylococcus aureus (MRSA) has brought us to explore further isosteric substitutions within the scaffold. Although our previous findings ha
NEW CLASS OF DNA GYRASE AND/OR TOPOISOMERASE IV INHIBITORS WITH ACTIVITY AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
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Page/Page column 102, (2020/03/29)
The present invention relates to compounds having a structure of general formula (I), processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in humans and warm-blooded animals.