105601-04-5Relevant articles and documents
Purification method of carafine intermediate
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Paragraph 0021, (2021/10/02)
To 3 - hydroxyacetophenone as a raw material, the intermediate 3 - [1 - (dimethylamino) ethyl] phenol is formed by reaction with dimethylamine, and the intermediate is subjected to resolution and purification by a specific resolution system to obtain S - 3 - [1 - (dimethylamino) ethyl] phenol. Compared with the preparation method of the intermediate prepared by the method, the preparation method has the advantages of low cost, high yield, good effect, less environmental pollution, reduced residue of inorganic salt, and favorability for large-scale industrial production.
2,4-bis-substituted acetophenone compound, optical isomers and pharmaceutically acceptable salts thereof and application of 2,4-bis-substituted acetophenone compound and optical isomers and pharmaceutically acceptable salts thereof
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, (2017/12/28)
The invention relates to a 2,4-bis-substituted acetophenone compound and optical isomers and pharmaceutically acceptable salts thereof. The invention further discloses an application of the 2,4-bis-substituted acetophenone compound and the optical isomers and pharmaceutically acceptable salts thereof in the aspect of treatment of neural degeneration diseases. The novel compounds have acetylcholinesterase inhibition activity and A beta aggregation inhibiting ability, and hydrolyzates of the novel compounds further have a metal ion chelation action, so that the novel compounds can be used for carrying out treatment from a plurality of targets and have a better application prospect in the treatment of the neural degeneration diseases.
1 -(DIMETHYLAMINO)ETHYL-SUBSTITUTED 6H-BENZO[C]CHROMEN-6-ONES AGAINST SENILE DEMENTIA
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Page/Page column 8; 9, (2014/09/03)
This invention relates to novel (±)1-(Dimethylamino)ethyl substituted 6H-benzo[c]chromen-6-one compounds which are useful as pharmaceutical compositions.
