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CAS No.: | 80-11-5 |
---|---|
Name: | N-Methyl-N-nitrosotoluene-4-sulphonamide |
Article Data: | 18 |
Molecular Structure: | |
Formula: | C8H10N2O3S |
Molecular Weight: | 214.245 |
Synonyms: | p-Toluenesulfonamide,N-methyl-N-nitroso- (6CI,7CI,8CI);Diazald;Diazale;N-Methyl-N-nitroso-4-tosylamide;N-Nitroso-N-methyl-p-toluenesulfonamide;NSC 313;p-Tolylsulfonylmethylnitrosamide; |
EINECS: | 201-252-6 |
Density: | 1.3 g/cm3 |
Melting Point: | ~58 °C |
Boiling Point: | 320.5 °C at 760 mmHg |
Flash Point: | 147.6 °C |
Appearance: | pale yellow crystalline powder |
Hazard Symbols: | E,Xi,Xn |
Risk Codes: | 2-36/37/38-43-20/21/22 |
Safety: | 15-26-35-36/37-36 |
Transport Information: | UN 3234 4.1/PG 2 |
PSA: | 75.19000 |
LogP: | 2.37770 |
Conditions | Yield |
---|---|
With hydrogenchloride; water; sodium nitrite In diethyl ether | 81% |
With perchloric acid; sodium nitrite In dichloromethane; water Rate constant; Equilibrium constant; nitrosation of substituted N-methylbenzenesulfonamides; reversibility; kinetics of nitrosation and denitrosation; substituent effect; acid catalysis; effect of nucleophiles; mechanism; | |
With dinitrogen tetraoxide |
Conditions | Yield |
---|---|
With sodium hydroxide Behandeln des Reaktionsgemisches mit Essigsaeure und NaNO2; |
cyclopentyl nitrite
N-methyl-p-toluenesulfonylamide
N-methyl-N-nitrosotoluene-p-sulfonamide
Conditions | Yield |
---|---|
With diluted acid |
1-methyl-1-(4-tolylsulfonyl)hydrazine
N-methyl-N-nitrosotoluene-p-sulfonamide
Conditions | Yield |
---|---|
With trifluoroacetic acid; sodium nitrite |
p-toluenesulfonyl chloride
(Z)-potassium methanediazotate
N-methyl-N-nitrosotoluene-p-sulfonamide
Conditions | Yield |
---|---|
In diethyl ether |
C8H10NO2S(1-)
N-methyl-N-nitrosotoluene-p-sulfonamide
Conditions | Yield |
---|---|
With nitrosonium perchlorate In acetonitrile at 25℃; Thermodynamic data; |
N-methyl-N-nitrosotoluene-p-sulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trifluoroacetic acid / neat (no solvent) / 1 h / 0 - 23 °C 2: sodium chloride; sodium acetate; sodium nitrite; acetic acid / water / 0.25 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
With sulfite(2-) In 1,4-dioxane; water at 25℃; Rate constant; | 100% |
With Thiocyanate In 1,4-dioxane; water at 25℃; Rate constant; | 100% |
With thiourea In 1,4-dioxane; water at 25℃; Rate constant; | 100% |
N-methyl-N-nitrosotoluene-p-sulfonamide
N-Boc-D-serine(Bzl)-OH
(R)-3-benzyloxy-2-tert-butoxycarbonyl-amino-propionic acid methyl ester
Conditions | Yield |
---|---|
99% |
2-Amino-5-methylbenzoic acid
N-methyl-N-nitrosotoluene-p-sulfonamide
2-amino-5-methylbenzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: N-methyl-N-nitrosotoluene-p-sulfonamide With potassium hydroxide In diethyl ether; water Stage #2: 2-Amino-5-methylbenzoic acid In diethyl ether for 1h; | 99% |
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Molecular Formula: C8H10N2O3S
Molecular Weight: 214.24
EINECS: 201-252-6
Density: 1.3 g/cm3
Flash Point: 147.6 °C
Storage temp: 2-8°C
Index of Refraction: 1.572
Enthalpy of Vaporization: 56.22 kJ/mol
Boiling Point: 320.5 °C at 760 mmHg
Vapour Pressure: 0.000317 mmHg at 25°C
Appearance: pale yellow crystalline powder
Product Categories: Pharmaceutical Intermediates
Stability: Stable, but heat sensitive; may also be light sensitive. Incompatible with strong oxidizing agents, alkalies.
Synonyms: Benzenesulfonamide, N,4-dimethyl-N-nitroso- ; Benzenesulfonamide,N,4-dimethyl-N-nitroso- ; Diazale;diazalo ; Methylnitroso-p-toluenesulfonamide ; N,4-dimethyl-n-nitroso-benzenesulfonamid ; N,4-dimethyl-N-nitroso-Benzenesulfonamide ; N,4-Dimethyl-N'-oxobenzenesulfonohydrazide
Following is the molecular structure of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):
The toxicity of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 19mg/kg (19mg/kg) | Cancer Research. Vol. 30, Pg. 11, 1970. | |
rat | LD50 | oral | 2700mg/kg (2700mg/kg) | Naturwissenschaften. Vol. 48, Pg. 165, 1961. |
Safety Information of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):
Hazard Codes: E,Xi,Xn
E: Explosive Xn: Harmful Xi: Irritant
Risk Statements: 2-36/37/38-43-20/21/22
2: Risk of explosion by shock, friction, fire or other sources of ignition
36/37/38: Irritating to eyes, respiratory system and skin
43: May cause sensitization by skin contact
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 15-26-35-36/37-36
15: Keep away from heat
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
35: This material and its container must be disposed of in a safe way
36/37: Wear suitable protective clothing and gloves
36: Wear suitable protective clothing
RIDADR: UN 3234 4.1/PG 2
WGK Germany: 2
RTECS: XT5950000
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 80-11-5(Hazardous Substances Data)